UDS-test with freon 11 (R-11)
Trichlorofluoromethane, in concentrations of 80, 400, 2 000, 10 000 and 50 000 ppm, was administered to rats of both sexes (Sprague Dawley) by inhalation exposure.2 000 ppm in air (= 11 200 mg/m(3)) amount to twice the MAK value of 1 000 ppm. At exposure times of 4 hours this corresponds to the MAK...
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| Veröffentlicht in: | Environmental science and pollution research international 1995-07, Vol.2 (4), p.233-236 |
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| container_title | Environmental science and pollution research international |
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| creator | Winker, N Klein, W Weniger, P Ott, E Hofer, H |
| description | Trichlorofluoromethane, in concentrations of 80, 400, 2 000, 10 000 and 50 000 ppm, was administered to rats of both sexes (Sprague Dawley) by inhalation exposure.2 000 ppm in air (= 11 200 mg/m(3)) amount to twice the MAK value of 1 000 ppm. At exposure times of 4 hours this corresponds to the MAK value defined for an 8 hour workday.Unscheduled DNA synthesis (UDS) was measured in single-cell suspensions of hepatocytes, pulmonary epithelial cells and lymphocytes of the spleen, respectively.In the pulmonary cells concentrations of 2 000, 10 000 and 50 000 ppm of freon 11 lead to a significantly increased mean silver grain count compared to a negative control group.In spleen and liver cells increasing concentrations of R 11 tend to increase the incorporation of thymidine into the DNA of the cells. These changes of the extent of unscheduled DNA synthesis can, however, not be statistically verified. |
| doi_str_mv | 10.1007/BF02986772 |
| format | Article |
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At exposure times of 4 hours this corresponds to the MAK value defined for an 8 hour workday.Unscheduled DNA synthesis (UDS) was measured in single-cell suspensions of hepatocytes, pulmonary epithelial cells and lymphocytes of the spleen, respectively.In the pulmonary cells concentrations of 2 000, 10 000 and 50 000 ppm of freon 11 lead to a significantly increased mean silver grain count compared to a negative control group.In spleen and liver cells increasing concentrations of R 11 tend to increase the incorporation of thymidine into the DNA of the cells. 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| source | Springer Nature - Complete Springer Journals |
| title | UDS-test with freon 11 (R-11) |
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