Unfolding and Folding Kinetics of Amyotrophic Lateral Sclerosis-Associated Mutant Cu,Zn Superoxide Dismutases

More than 110 mutations in dimeric, Cu,Zn superoxide dismutase (SOD) have been linked to the fatal neurodegenerative disease, amyotrophic lateral sclerosis (ALS). In both human patients and mouse model studies, protein misfolding has been implicated in disease pathogenesis. A central step in underst...

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Veröffentlicht in:Journal of molecular biology 2009-01, Vol.385 (1), p.278-298
Hauptverfasser: Rumfeldt, Jessica A.O., Lepock, James R., Meiering, Elizabeth M.
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Sprache:eng
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