Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia
An increased risk of hemorrhagic transformation is a major factor limiting the use of tissue plasminogen activator for stroke. Increased hemorrhagic transformation is also found in animals undergoing transient focal cerebral ischemia with hyperglycemia; this study examined whether hyperbaric oxygen...
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| Veröffentlicht in: | Stroke (1970) 2007-04, Vol.38 (4), p.1362-1367 |
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| container_title | Stroke (1970) |
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| creator | ZHIYONG QIN KARABIYIKOGLU, Murat YA HUA SILBERGLEIT, Robert YANGDONG HE KEEP, Richard F GUOHUA XI |
| description | An increased risk of hemorrhagic transformation is a major factor limiting the use of tissue plasminogen activator for stroke. Increased hemorrhagic transformation is also found in animals undergoing transient focal cerebral ischemia with hyperglycemia; this study examined whether hyperbaric oxygen (HBO) could reduce such hemorrhagic transformation in a rat model.
Rats received an injection of 50% glucose (6 mL/kg intraperitoneally) and had a middle cerebral artery occlusion 10 minutes later. Rats were treated with HBO (3 ATA for 1 hour) 30 minutes after middle cerebral artery occlusion. Control rats received normobaric room air. Rats underwent reperfusion 2 hours after middle cerebral artery occlusion. Blood-brain barrier permeability (Evans blue), hemorrhagic transformation (hemoglobin content), brain edema, infarct volume, and mortality were measured.
HBO treatment reduced Evans blue leakage in the ipsilateral hemisphere (28.4+/-3.5 versus 71.8+/-13.1 microg/g in control group, P |
| doi_str_mv | 10.1161/01.str.0000259660.62865.eb |
| format | Article |
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Rats received an injection of 50% glucose (6 mL/kg intraperitoneally) and had a middle cerebral artery occlusion 10 minutes later. Rats were treated with HBO (3 ATA for 1 hour) 30 minutes after middle cerebral artery occlusion. Control rats received normobaric room air. Rats underwent reperfusion 2 hours after middle cerebral artery occlusion. Blood-brain barrier permeability (Evans blue), hemorrhagic transformation (hemoglobin content), brain edema, infarct volume, and mortality were measured.
HBO treatment reduced Evans blue leakage in the ipsilateral hemisphere (28.4+/-3.5 versus 71.8+/-13.1 microg/g in control group, P<0.01) 2 hours after reperfusion and hemorrhagic transformation (0.13+/-0.13 versus 0.31+/-0.28 mg hemoglobin in the control group, P<0.05) 22 hours later. Mortality was less in the HBO group (4% versus 27% in controls, P<0.05). Mean infarct volume and swelling in the caudate were also less in HBO-treated rats (P<0.05), but HBO failed to reduce brain water content in the ipsilateral hemisphere (P>0.05).
Early intraischemic HBO treatment reduces the blood-brain barrier disruption, hemorrhagic transformation, and mortality after focal cerebral ischemia suggesting that HBO could be used to reduce hemorrhagic conversion in patients with stroke.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.str.0000259660.62865.eb</identifier><identifier>PMID: 17322079</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - physiopathology ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebral Hemorrhage - etiology ; Cerebral Hemorrhage - physiopathology ; Cerebral Hemorrhage - prevention & control ; Cerebral Infarction - complications ; Cerebral Infarction - physiopathology ; Disease Models, Animal ; Fibrinolytic Agents - adverse effects ; Fundamental and applied biological sciences. Psychology ; Hemoglobins - metabolism ; Hyperbaric Oxygenation - methods ; Infarction, Middle Cerebral Artery - complications ; Infarction, Middle Cerebral Artery - physiopathology ; Ischemic Attack, Transient - complications ; Ischemic Attack, Transient - physiopathology ; Male ; Medical sciences ; Neurology ; Neuropharmacology ; Neuroprotective agent ; Oxygen - pharmacology ; Oxygen - therapeutic use ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - complications ; Reperfusion Injury - physiopathology ; Tissue Plasminogen Activator - adverse effects ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system ; Vertebrates: nervous system and sense organs</subject><ispartof>Stroke (1970), 2007-04, Vol.38 (4), p.1362-1367</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-8a96076d85f0a57fc669142db260084d33101072ac3b3c27963943c6e8b2b3043</citedby><cites>FETCH-LOGICAL-c532t-8a96076d85f0a57fc669142db260084d33101072ac3b3c27963943c6e8b2b3043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18639055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17322079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZHIYONG QIN</creatorcontrib><creatorcontrib>KARABIYIKOGLU, Murat</creatorcontrib><creatorcontrib>YA HUA</creatorcontrib><creatorcontrib>SILBERGLEIT, Robert</creatorcontrib><creatorcontrib>YANGDONG HE</creatorcontrib><creatorcontrib>KEEP, Richard F</creatorcontrib><creatorcontrib>GUOHUA XI</creatorcontrib><title>Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>An increased risk of hemorrhagic transformation is a major factor limiting the use of tissue plasminogen activator for stroke. Increased hemorrhagic transformation is also found in animals undergoing transient focal cerebral ischemia with hyperglycemia; this study examined whether hyperbaric oxygen (HBO) could reduce such hemorrhagic transformation in a rat model.
Rats received an injection of 50% glucose (6 mL/kg intraperitoneally) and had a middle cerebral artery occlusion 10 minutes later. Rats were treated with HBO (3 ATA for 1 hour) 30 minutes after middle cerebral artery occlusion. Control rats received normobaric room air. Rats underwent reperfusion 2 hours after middle cerebral artery occlusion. Blood-brain barrier permeability (Evans blue), hemorrhagic transformation (hemoglobin content), brain edema, infarct volume, and mortality were measured.
HBO treatment reduced Evans blue leakage in the ipsilateral hemisphere (28.4+/-3.5 versus 71.8+/-13.1 microg/g in control group, P<0.01) 2 hours after reperfusion and hemorrhagic transformation (0.13+/-0.13 versus 0.31+/-0.28 mg hemoglobin in the control group, P<0.05) 22 hours later. Mortality was less in the HBO group (4% versus 27% in controls, P<0.05). Mean infarct volume and swelling in the caudate were also less in HBO-treated rats (P<0.05), but HBO failed to reduce brain water content in the ipsilateral hemisphere (P>0.05).
Early intraischemic HBO treatment reduces the blood-brain barrier disruption, hemorrhagic transformation, and mortality after focal cerebral ischemia suggesting that HBO could be used to reduce hemorrhagic conversion in patients with stroke.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiopathology</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebral Hemorrhage - etiology</subject><subject>Cerebral Hemorrhage - physiopathology</subject><subject>Cerebral Hemorrhage - prevention & control</subject><subject>Cerebral Infarction - complications</subject><subject>Cerebral Infarction - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Fibrinolytic Agents - adverse effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemoglobins - metabolism</subject><subject>Hyperbaric Oxygenation - methods</subject><subject>Infarction, Middle Cerebral Artery - complications</subject><subject>Infarction, Middle Cerebral Artery - physiopathology</subject><subject>Ischemic Attack, Transient - complications</subject><subject>Ischemic Attack, Transient - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Oxygen - pharmacology</subject><subject>Oxygen - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - complications</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Tissue Plasminogen Activator - adverse effects</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNFqHCEUhqW0NNu0rxCGQHM306OOzti7EpKmECi0ybWoc0wm7IwbdWD37eNmF9YLheN3fo8fIZcUGkol_QG0STk2UBYTSkpoJOulaNB-ICsqWFu3pfCRrAC4qlmr1Bn5ktLLnue9-EzOaMcZg06tyPZut8FoTRxdFba7J5zrcR4Wh0NlcsZ5MXkMcxV89YxTiPHZPBUyRzMnH-J0uDU-Y6xwW5LGCeds1pUPruzv3FgqlcOINpbSmFxJGs1X8smbdcJvx_OcPN7ePFzf1fd_f_-5_nVfO8FZrnujJHRy6IUHIzrvpFS0ZYNlEqBvB84pUOiYcdxyxzoluWq5k9hbZjm0_JxcHXI3MbwumLKeygi4XpsZw5I0A1YMClHAnwfQxZBSRK835Tcm7jQFvfeuger_D__0ybt-967RluaL4yuLnXA4tR5FF-D7ETCpmPFFjBvTievL3Psp3gB7j48N</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>ZHIYONG QIN</creator><creator>KARABIYIKOGLU, Murat</creator><creator>YA HUA</creator><creator>SILBERGLEIT, Robert</creator><creator>YANGDONG HE</creator><creator>KEEP, Richard F</creator><creator>GUOHUA XI</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20070401</creationdate><title>Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia</title><author>ZHIYONG QIN ; KARABIYIKOGLU, Murat ; YA HUA ; SILBERGLEIT, Robert ; YANGDONG HE ; KEEP, Richard F ; GUOHUA XI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-8a96076d85f0a57fc669142db260084d33101072ac3b3c27963943c6e8b2b3043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - physiopathology</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Cerebral Hemorrhage - physiopathology</topic><topic>Cerebral Hemorrhage - prevention & control</topic><topic>Cerebral Infarction - complications</topic><topic>Cerebral Infarction - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Fibrinolytic Agents - adverse effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemoglobins - metabolism</topic><topic>Hyperbaric Oxygenation - methods</topic><topic>Infarction, Middle Cerebral Artery - complications</topic><topic>Infarction, Middle Cerebral Artery - physiopathology</topic><topic>Ischemic Attack, Transient - complications</topic><topic>Ischemic Attack, Transient - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Oxygen - pharmacology</topic><topic>Oxygen - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - complications</topic><topic>Reperfusion Injury - physiopathology</topic><topic>Tissue Plasminogen Activator - adverse effects</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZHIYONG QIN</creatorcontrib><creatorcontrib>KARABIYIKOGLU, Murat</creatorcontrib><creatorcontrib>YA HUA</creatorcontrib><creatorcontrib>SILBERGLEIT, Robert</creatorcontrib><creatorcontrib>YANGDONG HE</creatorcontrib><creatorcontrib>KEEP, Richard F</creatorcontrib><creatorcontrib>GUOHUA XI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZHIYONG QIN</au><au>KARABIYIKOGLU, Murat</au><au>YA HUA</au><au>SILBERGLEIT, Robert</au><au>YANGDONG HE</au><au>KEEP, Richard F</au><au>GUOHUA XI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>38</volume><issue>4</issue><spage>1362</spage><epage>1367</epage><pages>1362-1367</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>An increased risk of hemorrhagic transformation is a major factor limiting the use of tissue plasminogen activator for stroke. Increased hemorrhagic transformation is also found in animals undergoing transient focal cerebral ischemia with hyperglycemia; this study examined whether hyperbaric oxygen (HBO) could reduce such hemorrhagic transformation in a rat model.
Rats received an injection of 50% glucose (6 mL/kg intraperitoneally) and had a middle cerebral artery occlusion 10 minutes later. Rats were treated with HBO (3 ATA for 1 hour) 30 minutes after middle cerebral artery occlusion. Control rats received normobaric room air. Rats underwent reperfusion 2 hours after middle cerebral artery occlusion. Blood-brain barrier permeability (Evans blue), hemorrhagic transformation (hemoglobin content), brain edema, infarct volume, and mortality were measured.
HBO treatment reduced Evans blue leakage in the ipsilateral hemisphere (28.4+/-3.5 versus 71.8+/-13.1 microg/g in control group, P<0.01) 2 hours after reperfusion and hemorrhagic transformation (0.13+/-0.13 versus 0.31+/-0.28 mg hemoglobin in the control group, P<0.05) 22 hours later. Mortality was less in the HBO group (4% versus 27% in controls, P<0.05). Mean infarct volume and swelling in the caudate were also less in HBO-treated rats (P<0.05), but HBO failed to reduce brain water content in the ipsilateral hemisphere (P>0.05).
Early intraischemic HBO treatment reduces the blood-brain barrier disruption, hemorrhagic transformation, and mortality after focal cerebral ischemia suggesting that HBO could be used to reduce hemorrhagic conversion in patients with stroke.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>17322079</pmid><doi>10.1161/01.str.0000259660.62865.eb</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiopathology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Hemorrhage - etiology Cerebral Hemorrhage - physiopathology Cerebral Hemorrhage - prevention & control Cerebral Infarction - complications Cerebral Infarction - physiopathology Disease Models, Animal Fibrinolytic Agents - adverse effects Fundamental and applied biological sciences. Psychology Hemoglobins - metabolism Hyperbaric Oxygenation - methods Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - physiopathology Ischemic Attack, Transient - complications Ischemic Attack, Transient - physiopathology Male Medical sciences Neurology Neuropharmacology Neuroprotective agent Oxygen - pharmacology Oxygen - therapeutic use Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reperfusion Injury - complications Reperfusion Injury - physiopathology Tissue Plasminogen Activator - adverse effects Treatment Outcome Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs |
| title | Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia |
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