E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury

The E3 ubiquitin ligase Cblb has a crucial role in the prevention of chronic inflammation and autoimmunity. Here we show that Cblb also has an unexpected function in acute lung inflammation. Cblb attenuates the sequestration of inflammatory cells in the lungs after administration of lipopolysacchari...

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Veröffentlicht in:	Nature medicine 2007-08, Vol.13 (7), p.920-926
Hauptverfasser:	Bachmaier, Kurt, Toya, Sophie, Gao, Xiaopei, Triantafillou, Thomas, Garrean, Sean, Park, Gye Young, Frey, Randall S, Vogel, Stephen, Minshall, Richard, Christman, John W, Tiruppathi, Chinnaswamy, Malik, Asrar B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Biomedical research Biomedicine Cancer Research Cellular biology Cytokines - biosynthesis Gene Deletion Gene Expression Regulation, Enzymologic Infectious Diseases Inflammatory diseases Lipopolysaccharides - pharmacology Lung - drug effects Lung - enzymology Lung - pathology Lung Injury Metabolic Diseases Mice Mice, Inbred BALB C Mice, Knockout Molecular Medicine Mutation Myeloid Differentiation Factor 88 - metabolism Neurosciences NF-kappa B - metabolism Phenotype Pneumonia - chemically induced Pneumonia - enzymology Pneumonia - genetics Pneumonia - pathology Prevention Protein Binding Protein Transport Proto-Oncogene Proteins c-cbl - deficiency Proto-Oncogene Proteins c-cbl - genetics Proto-Oncogene Proteins c-cbl - metabolism Respiratory diseases Signal Transduction Survival Rate Toll-Like Receptor 4 - metabolism
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