Examination of the relationship between disease activity and patient‐reported outcome measures in an inflammatory bowel disease cohort
Background The extent to which disease activity impacts patient‐reported outcomes (PRO) is unclear. Aims To examine the relationship between disease activity and PRO. Methods Adult inflammatory bowel disease (IBD) patients attending a tertiary clinic from May to June 2015 were included. Assessment o...
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| Veröffentlicht in: | Internal medicine journal 2018-10, Vol.48 (10), p.1234-1241 |
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| creator | Jackson, Belinda D. Con, Danny Gorelik, Alexandra Liew, Danny Knowles, Simon De Cruz, Peter |
| description | Background
The extent to which disease activity impacts patient‐reported outcomes (PRO) is unclear.
Aims
To examine the relationship between disease activity and PRO.
Methods
Adult inflammatory bowel disease (IBD) patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (Simple Clinical Colitis Activity Index (SCCAI), Harvey Bradshaw Index (HBI)), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (Hospital Anxiety and Depression Scale (HADS)), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PRO.
Results
A total of 81 participants was included: 49% female, 57% Crohn disease (CD), 38% ulcerative colitis (UC) and 5% IBD‐unclassified, with a median age of 34 years. At least mild levels of depression were present in 21 of 81 (26%) of patients; 37 of 81 (46%) expressed some level of anxiety. A moderate‐to‐strong correlation was found between disease activity and depression in UC (r = 0.84, P = 0.002) but not in CD (r = 0.53, P = 0.29). Disease activity correlated with: overall work impairment due to health (r = 0.85, P = 0.001), health‐related impairment while working (r = 0.76, P = 0.02) and percentage of activity impaired due to health (r = 0.83, P = 0.002) in UC only.
Conclusions
Disease activity significantly affects mood and work productivity in patients with UC. Monitoring patients’ ability to function and work, rather than minimising disease activity alone, should become a routine part of IBD care. |
| doi_str_mv | 10.1111/imj.13937 |
| format | Article |
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The extent to which disease activity impacts patient‐reported outcomes (PRO) is unclear.
Aims
To examine the relationship between disease activity and PRO.
Methods
Adult inflammatory bowel disease (IBD) patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (Simple Clinical Colitis Activity Index (SCCAI), Harvey Bradshaw Index (HBI)), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (Hospital Anxiety and Depression Scale (HADS)), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PRO.
Results
A total of 81 participants was included: 49% female, 57% Crohn disease (CD), 38% ulcerative colitis (UC) and 5% IBD‐unclassified, with a median age of 34 years. At least mild levels of depression were present in 21 of 81 (26%) of patients; 37 of 81 (46%) expressed some level of anxiety. A moderate‐to‐strong correlation was found between disease activity and depression in UC (r = 0.84, P = 0.002) but not in CD (r = 0.53, P = 0.29). Disease activity correlated with: overall work impairment due to health (r = 0.85, P = 0.001), health‐related impairment while working (r = 0.76, P = 0.02) and percentage of activity impaired due to health (r = 0.83, P = 0.002) in UC only.
Conclusions
Disease activity significantly affects mood and work productivity in patients with UC. Monitoring patients’ ability to function and work, rather than minimising disease activity alone, should become a routine part of IBD care.</description><identifier>ISSN: 1444-0903</identifier><identifier>EISSN: 1445-5994</identifier><identifier>DOI: 10.1111/imj.13937</identifier><identifier>PMID: 29663629</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adult ; Anxiety ; Australia - epidemiology ; Colon ; Crohn disease ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - epidemiology ; Inflammatory Bowel Diseases - physiopathology ; Inflammatory Bowel Diseases - psychology ; Inflammatory Bowel Diseases - therapy ; Intestine ; Male ; Mental depression ; Mood ; Patient Reported Outcome Measures ; Patients ; patient‐reported outcomes ; Prospective Studies ; Quality of life ; Quality of Life - psychology ; Severity of Illness Index ; Sickness Impact Profile ; Ulcerative colitis ; work productivity</subject><ispartof>Internal medicine journal, 2018-10, Vol.48 (10), p.1234-1241</ispartof><rights>2018 Royal Australasian College of Physicians</rights><rights>2018 Royal Australasian College of Physicians.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-bd7f7c8c59873c6c0638d91b999c58611768b0e3c8f434ccb94f3237ca27d4273</citedby><cites>FETCH-LOGICAL-c3887-bd7f7c8c59873c6c0638d91b999c58611768b0e3c8f434ccb94f3237ca27d4273</cites><orcidid>0000-0002-9232-5480</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimj.13937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimj.13937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29663629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, Belinda D.</creatorcontrib><creatorcontrib>Con, Danny</creatorcontrib><creatorcontrib>Gorelik, Alexandra</creatorcontrib><creatorcontrib>Liew, Danny</creatorcontrib><creatorcontrib>Knowles, Simon</creatorcontrib><creatorcontrib>De Cruz, Peter</creatorcontrib><title>Examination of the relationship between disease activity and patient‐reported outcome measures in an inflammatory bowel disease cohort</title><title>Internal medicine journal</title><addtitle>Intern Med J</addtitle><description>Background
The extent to which disease activity impacts patient‐reported outcomes (PRO) is unclear.
Aims
To examine the relationship between disease activity and PRO.
Methods
Adult inflammatory bowel disease (IBD) patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (Simple Clinical Colitis Activity Index (SCCAI), Harvey Bradshaw Index (HBI)), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (Hospital Anxiety and Depression Scale (HADS)), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PRO.
Results
A total of 81 participants was included: 49% female, 57% Crohn disease (CD), 38% ulcerative colitis (UC) and 5% IBD‐unclassified, with a median age of 34 years. At least mild levels of depression were present in 21 of 81 (26%) of patients; 37 of 81 (46%) expressed some level of anxiety. A moderate‐to‐strong correlation was found between disease activity and depression in UC (r = 0.84, P = 0.002) but not in CD (r = 0.53, P = 0.29). Disease activity correlated with: overall work impairment due to health (r = 0.85, P = 0.001), health‐related impairment while working (r = 0.76, P = 0.02) and percentage of activity impaired due to health (r = 0.83, P = 0.002) in UC only.
Conclusions
Disease activity significantly affects mood and work productivity in patients with UC. Monitoring patients’ ability to function and work, rather than minimising disease activity alone, should become a routine part of IBD care.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Australia - epidemiology</subject><subject>Colon</subject><subject>Crohn disease</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Inflammatory Bowel Diseases - physiopathology</subject><subject>Inflammatory Bowel Diseases - psychology</subject><subject>Inflammatory Bowel Diseases - therapy</subject><subject>Intestine</subject><subject>Male</subject><subject>Mental depression</subject><subject>Mood</subject><subject>Patient Reported Outcome Measures</subject><subject>Patients</subject><subject>patient‐reported outcomes</subject><subject>Prospective Studies</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Severity of Illness Index</subject><subject>Sickness Impact Profile</subject><subject>Ulcerative colitis</subject><subject>work productivity</subject><issn>1444-0903</issn><issn>1445-5994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U9vFCEYBnBiNLZWD34BQ-JFD9Pyb2A4mqZqTY0XPROGeSfLZhhGYLruzaNHP6OfRNytPZjIAV6SH09IHoSeU3JO67rwYXtOuebqATqlQrRNq7V4eJhFQzThJ-hJzltCqOJaPEYnTEvJJdOn6MfVNxv8bIuPM44jLhvACabDPW_8gnsoO4AZDz6DzYCtK_7Wlz2284CX6mAuv77_TLDEVGDAcS0uBsCh6jVBxn6utO7jZEOwJaY97uMOpvtEFzf16VP0aLRThmd35xn68vbq8-X75ubTu-vLNzeN412nmn5Qo3Kda3WnuJOOSN4NmvZaa9d2klIlu54Ad90ouHCu12LkjCtnmRoEU_wMvTrmLil-XSEXE3x2ME12hrhmwwiTghGhdaUv_6HbuKa5_s4wSiUjipO2qtdH5VLMOcFoluSDTXtDiflTj6n1mEM91b64S1z7AMO9_NtHBRdHsPMT7P-fZK4_fjhG_gberJyB</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Jackson, Belinda D.</creator><creator>Con, Danny</creator><creator>Gorelik, Alexandra</creator><creator>Liew, Danny</creator><creator>Knowles, Simon</creator><creator>De Cruz, Peter</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9232-5480</orcidid></search><sort><creationdate>201810</creationdate><title>Examination of the relationship between disease activity and patient‐reported outcome measures in an inflammatory bowel disease cohort</title><author>Jackson, Belinda D. ; Con, Danny ; Gorelik, Alexandra ; Liew, Danny ; Knowles, Simon ; De Cruz, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-bd7f7c8c59873c6c0638d91b999c58611768b0e3c8f434ccb94f3237ca27d4273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Australia - epidemiology</topic><topic>Colon</topic><topic>Crohn disease</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Inflammatory Bowel Diseases - physiopathology</topic><topic>Inflammatory Bowel Diseases - psychology</topic><topic>Inflammatory Bowel Diseases - therapy</topic><topic>Intestine</topic><topic>Male</topic><topic>Mental depression</topic><topic>Mood</topic><topic>Patient Reported Outcome Measures</topic><topic>Patients</topic><topic>patient‐reported outcomes</topic><topic>Prospective Studies</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Severity of Illness Index</topic><topic>Sickness Impact Profile</topic><topic>Ulcerative colitis</topic><topic>work productivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Belinda D.</creatorcontrib><creatorcontrib>Con, Danny</creatorcontrib><creatorcontrib>Gorelik, Alexandra</creatorcontrib><creatorcontrib>Liew, Danny</creatorcontrib><creatorcontrib>Knowles, Simon</creatorcontrib><creatorcontrib>De Cruz, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Internal medicine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Belinda D.</au><au>Con, Danny</au><au>Gorelik, Alexandra</au><au>Liew, Danny</au><au>Knowles, Simon</au><au>De Cruz, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of the relationship between disease activity and patient‐reported outcome measures in an inflammatory bowel disease cohort</atitle><jtitle>Internal medicine journal</jtitle><addtitle>Intern Med J</addtitle><date>2018-10</date><risdate>2018</risdate><volume>48</volume><issue>10</issue><spage>1234</spage><epage>1241</epage><pages>1234-1241</pages><issn>1444-0903</issn><eissn>1445-5994</eissn><abstract>Background
The extent to which disease activity impacts patient‐reported outcomes (PRO) is unclear.
Aims
To examine the relationship between disease activity and PRO.
Methods
Adult inflammatory bowel disease (IBD) patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (Simple Clinical Colitis Activity Index (SCCAI), Harvey Bradshaw Index (HBI)), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (Hospital Anxiety and Depression Scale (HADS)), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PRO.
Results
A total of 81 participants was included: 49% female, 57% Crohn disease (CD), 38% ulcerative colitis (UC) and 5% IBD‐unclassified, with a median age of 34 years. At least mild levels of depression were present in 21 of 81 (26%) of patients; 37 of 81 (46%) expressed some level of anxiety. A moderate‐to‐strong correlation was found between disease activity and depression in UC (r = 0.84, P = 0.002) but not in CD (r = 0.53, P = 0.29). Disease activity correlated with: overall work impairment due to health (r = 0.85, P = 0.001), health‐related impairment while working (r = 0.76, P = 0.02) and percentage of activity impaired due to health (r = 0.83, P = 0.002) in UC only.
Conclusions
Disease activity significantly affects mood and work productivity in patients with UC. Monitoring patients’ ability to function and work, rather than minimising disease activity alone, should become a routine part of IBD care.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>29663629</pmid><doi>10.1111/imj.13937</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9232-5480</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal medicine journal, 2018-10, Vol.48 (10), p.1234-1241 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Anxiety Australia - epidemiology Colon Crohn disease Cross-Sectional Studies Disease Progression Female Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - physiopathology Inflammatory Bowel Diseases - psychology Inflammatory Bowel Diseases - therapy Intestine Male Mental depression Mood Patient Reported Outcome Measures Patients patient‐reported outcomes Prospective Studies Quality of life Quality of Life - psychology Severity of Illness Index Sickness Impact Profile Ulcerative colitis work productivity |
| title | Examination of the relationship between disease activity and patient‐reported outcome measures in an inflammatory bowel disease cohort |
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