Palladium-Catalyzed Direct C–H Arylation of 3‑(Methylsulfinyl)thiophenes

Palladium-Catalyzed Direct C–H Arylation of 3‑(Methylsulfinyl)thiophenes

A palladium-catalyzed direct arylation of (3-thiophene)­S­(O)­Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerat...

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Veröffentlicht in:Organic letters 2018-05, Vol.20 (9), p.2522-2525
Hauptverfasser: Jiang, Hui, Bellomo, Ana, Zhang, Mengnan, Carroll, Patrick J, Manor, Brian C, Jia, Tiezheng, Walsh, Patrick J
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container_end_page 2525
container_issue 9
container_start_page 2522
container_title Organic letters
container_volume 20
creator Jiang, Hui
Bellomo, Ana
Zhang, Mengnan
Carroll, Patrick J
Manor, Brian C
Jia, Tiezheng
Walsh, Patrick J
description A palladium-catalyzed direct arylation of (3-thiophene)­S­(O)­Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)­thiophenes is also introduced.
doi_str_mv 10.1021/acs.orglett.8b00599
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title Palladium-Catalyzed Direct C–H Arylation of 3‑(Methylsulfinyl)thiophenes
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