Additional Screening and Treatment of Malaria During Pregnancy Provides Further Protection Against Malaria and Nonmalarial Fevers During the First Year of Life
Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants. In Burkina Faso, a birth cohort study was nested to a clinical tri...
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| Veröffentlicht in: | The Journal of infectious diseases 2018-05, Vol.217 (12), p.1967-1976 |
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| container_end_page | 1976 |
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| container_issue | 12 |
| container_start_page | 1967 |
| container_title | The Journal of infectious diseases |
| container_volume | 217 |
| creator | Natama, Hamtandi Magloire Rovira-Vallbona, Eduard Sorgho, Hermann Somé, M Athanase Traoré-Coulibaly, Maminata Scott, Susana Zango, Serge Henri Sawadogo, Ousséni Zongo, Sibiri Claude Valéa, Innocent Mens, Petra F Schallig, Henk D F H Kestens, Luc Tinto, Halidou Rosanas-Urgell, Anna |
| description | Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants.
In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs.
Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval, .55-0.99]; P = .047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed.
Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants. |
| doi_str_mv | 10.1093/infdis/jiy140 |
| format | Article |
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In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs.
Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval, .55-0.99]; P = .047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed.
Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiy140</identifier><identifier>PMID: 29659897</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Antimalarials - therapeutic use ; Burkina Faso ; Cohort Studies ; Drug Combinations ; Female ; Humans ; Incidence ; Infant ; Malaria, Falciparum - diagnosis ; Malaria, Falciparum - drug therapy ; Male ; Mass Screening - methods ; Plasmodium falciparum - drug effects ; Pregnancy ; Pregnancy Complications, Parasitic - diagnosis ; Pregnancy Complications, Parasitic - drug therapy ; Pyrimethamine - therapeutic use ; Sulfadoxine - therapeutic use</subject><ispartof>The Journal of infectious diseases, 2018-05, Vol.217 (12), p.1967-1976</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-b4258e07be0536175fe823863d15608d283fcd58af9c8a403b9ad7a005f24dd3</citedby><cites>FETCH-LOGICAL-c332t-b4258e07be0536175fe823863d15608d283fcd58af9c8a403b9ad7a005f24dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29659897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Natama, Hamtandi Magloire</creatorcontrib><creatorcontrib>Rovira-Vallbona, Eduard</creatorcontrib><creatorcontrib>Sorgho, Hermann</creatorcontrib><creatorcontrib>Somé, M Athanase</creatorcontrib><creatorcontrib>Traoré-Coulibaly, Maminata</creatorcontrib><creatorcontrib>Scott, Susana</creatorcontrib><creatorcontrib>Zango, Serge Henri</creatorcontrib><creatorcontrib>Sawadogo, Ousséni</creatorcontrib><creatorcontrib>Zongo, Sibiri Claude</creatorcontrib><creatorcontrib>Valéa, Innocent</creatorcontrib><creatorcontrib>Mens, Petra F</creatorcontrib><creatorcontrib>Schallig, Henk D F H</creatorcontrib><creatorcontrib>Kestens, Luc</creatorcontrib><creatorcontrib>Tinto, Halidou</creatorcontrib><creatorcontrib>Rosanas-Urgell, Anna</creatorcontrib><title>Additional Screening and Treatment of Malaria During Pregnancy Provides Further Protection Against Malaria and Nonmalarial Fevers During the First Year of Life</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants.
In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs.
Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval, .55-0.99]; P = .047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed.
Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.</description><subject>Adult</subject><subject>Antimalarials - therapeutic use</subject><subject>Burkina Faso</subject><subject>Cohort Studies</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Malaria, Falciparum - diagnosis</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - diagnosis</subject><subject>Pregnancy Complications, Parasitic - drug therapy</subject><subject>Pyrimethamine - therapeutic use</subject><subject>Sulfadoxine - therapeutic use</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kbtOwzAUhi0EgnIZWZFHllBfcrHHqhBAKheJLkyRGx8Xo8QpdlKpT8Orkigtk-1zvv_z8CN0TckdJZJPrTPahum33dGYHKEJTXgWpSnlx2hCCGMRFVKeofMQvgkhMU-zU3TGZJpIIbMJ-p1pbVvbOFXhj9IDOOvWWDmNlx5UW4NrcWPwi6qUtwrfd37Yv3tYO-XKXX9rtlZDwHnn2y_ww6CFcjDi2VpZF9r_8GB9bVw9PiucwxZ8ODj7NM6t7_lPUH74dGENXKITo6oAV_vzAi3zh-X8KVq8PT7PZ4uo5Jy10SpmiQCSrYAkPKVZYkAwLlKuaZISoZngptSJUEaWQsWEr6TSmSIkMSzWml-g21G78c1PB6EtahtKqCrloOlCwQhLY0qllD0ajWjpmxA8mGLjba38rqCkGCopxkqKsZKev9mru1UN-p8-dMD_AC_ai9U</recordid><startdate>20180525</startdate><enddate>20180525</enddate><creator>Natama, Hamtandi Magloire</creator><creator>Rovira-Vallbona, Eduard</creator><creator>Sorgho, Hermann</creator><creator>Somé, M Athanase</creator><creator>Traoré-Coulibaly, Maminata</creator><creator>Scott, Susana</creator><creator>Zango, Serge Henri</creator><creator>Sawadogo, Ousséni</creator><creator>Zongo, Sibiri Claude</creator><creator>Valéa, Innocent</creator><creator>Mens, Petra F</creator><creator>Schallig, Henk D F H</creator><creator>Kestens, Luc</creator><creator>Tinto, Halidou</creator><creator>Rosanas-Urgell, Anna</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180525</creationdate><title>Additional Screening and Treatment of Malaria During Pregnancy Provides Further Protection Against Malaria and Nonmalarial Fevers During the First Year of Life</title><author>Natama, Hamtandi Magloire ; Rovira-Vallbona, Eduard ; Sorgho, Hermann ; Somé, M Athanase ; Traoré-Coulibaly, Maminata ; Scott, Susana ; Zango, Serge Henri ; Sawadogo, Ousséni ; Zongo, Sibiri Claude ; Valéa, Innocent ; Mens, Petra F ; Schallig, Henk D F H ; Kestens, Luc ; Tinto, Halidou ; Rosanas-Urgell, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-b4258e07be0536175fe823863d15608d283fcd58af9c8a403b9ad7a005f24dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Antimalarials - therapeutic use</topic><topic>Burkina Faso</topic><topic>Cohort Studies</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Malaria, Falciparum - diagnosis</topic><topic>Malaria, Falciparum - drug therapy</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - diagnosis</topic><topic>Pregnancy Complications, Parasitic - drug therapy</topic><topic>Pyrimethamine - therapeutic use</topic><topic>Sulfadoxine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Natama, Hamtandi Magloire</creatorcontrib><creatorcontrib>Rovira-Vallbona, Eduard</creatorcontrib><creatorcontrib>Sorgho, Hermann</creatorcontrib><creatorcontrib>Somé, M Athanase</creatorcontrib><creatorcontrib>Traoré-Coulibaly, Maminata</creatorcontrib><creatorcontrib>Scott, Susana</creatorcontrib><creatorcontrib>Zango, Serge Henri</creatorcontrib><creatorcontrib>Sawadogo, Ousséni</creatorcontrib><creatorcontrib>Zongo, Sibiri Claude</creatorcontrib><creatorcontrib>Valéa, Innocent</creatorcontrib><creatorcontrib>Mens, Petra F</creatorcontrib><creatorcontrib>Schallig, Henk D F H</creatorcontrib><creatorcontrib>Kestens, Luc</creatorcontrib><creatorcontrib>Tinto, Halidou</creatorcontrib><creatorcontrib>Rosanas-Urgell, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Natama, Hamtandi Magloire</au><au>Rovira-Vallbona, Eduard</au><au>Sorgho, Hermann</au><au>Somé, M Athanase</au><au>Traoré-Coulibaly, Maminata</au><au>Scott, Susana</au><au>Zango, Serge Henri</au><au>Sawadogo, Ousséni</au><au>Zongo, Sibiri Claude</au><au>Valéa, Innocent</au><au>Mens, Petra F</au><au>Schallig, Henk D F H</au><au>Kestens, Luc</au><au>Tinto, Halidou</au><au>Rosanas-Urgell, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additional Screening and Treatment of Malaria During Pregnancy Provides Further Protection Against Malaria and Nonmalarial Fevers During the First Year of Life</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2018-05-25</date><risdate>2018</risdate><volume>217</volume><issue>12</issue><spage>1967</spage><epage>1976</epage><pages>1967-1976</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants.
In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effectiveness of a community-based scheduled screening and treatment of malaria in combination with intermittent preventive treatment with sulfadoxine-pyrimethamine (CSST/IPTp-SP) to prevent placental malaria. Clinical episodes and asymptomatic infections were monitored over 1 year of follow-up to compare the effect of CSST/IPTp-SP and standard IPTp-SP on malaria and NMFs.
Infants born during low-transmission season from mothers receiving CSST/IPTp-SP had a 26% decreased risk of experiencing a first clinical episode (hazard ratio, 0.74 [95% confidence interval, .55-0.99]; P = .047). CSST/IPTp-SP interacted with birth season and gravidity to reduce the incidence of NMFs. No significant effects of CSST/IPTp-SP on the incidence of clinical episodes, parasite density, and Plasmodium falciparum infections were observed.
Our findings indicate that CSST/IPTp-SP strategy may provide additional protection against both malaria and NMFs in infants during the first year of life, and suggest that malaria control interventions during pregnancy could have long-term benefits in infants.</abstract><cop>United States</cop><pmid>29659897</pmid><doi>10.1093/infdis/jiy140</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2018-05, Vol.217 (12), p.1967-1976 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Antimalarials - therapeutic use Burkina Faso Cohort Studies Drug Combinations Female Humans Incidence Infant Malaria, Falciparum - diagnosis Malaria, Falciparum - drug therapy Male Mass Screening - methods Plasmodium falciparum - drug effects Pregnancy Pregnancy Complications, Parasitic - diagnosis Pregnancy Complications, Parasitic - drug therapy Pyrimethamine - therapeutic use Sulfadoxine - therapeutic use |
| title | Additional Screening and Treatment of Malaria During Pregnancy Provides Further Protection Against Malaria and Nonmalarial Fevers During the First Year of Life |
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