Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population

Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population

Abstract BACKGROUND The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive indivi...

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Veröffentlicht in:American journal of hypertension 2018-07, Vol.31 (8), p.895-901
Hauptverfasser: Tanaka, Kentaro, Tanaka, Fumitaka, Onoda, Toshiyuki, Tanno, Kozo, Ohsawa, Masaki, Sakata, Kiyomi, Omama, Shinichi, Ogasawara, Kuniaki, Ishibashi, Yasuhiro, Itai, Kazuyoshi, Kuribayashi, Toru, Okayama, Akira, Nakamura, Motoyuki
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container_end_page 901
container_issue 8
container_start_page 895
container_title American journal of hypertension
container_volume 31
creator Tanaka, Kentaro
Tanaka, Fumitaka
Onoda, Toshiyuki
Tanno, Kozo
Ohsawa, Masaki
Sakata, Kiyomi
Omama, Shinichi
Ogasawara, Kuniaki
Ishibashi, Yasuhiro
Itai, Kazuyoshi
Kuribayashi, Toru
Okayama, Akira
Nakamura, Motoyuki
description Abstract BACKGROUND The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals. METHODS A total of 4,927 non-hypertensive individuals ≥40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP). RESULTS During the average 9.8 ± 2.0 years of follow-up, 267 individuals (5.4%) had their first CVE. The hazard ratio (HR) for the incidence of CVE after full adjustment by potential confounders significantly increased in the individuals with ECG-LVH by any criteria of the SL voltage, CV, and CP (HR = 1.77, P < 0.001) compared to those with no ECG-LVH. This association was also significant in individuals without any of obesity, dyslipidemia, and diabetes mellitus or those with systolic blood pressure (BP)
doi_str_mv 10.1093/ajh/hpy055
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METHODS A total of 4,927 non-hypertensive individuals ≥40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP). RESULTS During the average 9.8 ± 2.0 years of follow-up, 267 individuals (5.4%) had their first CVE. The hazard ratio (HR) for the incidence of CVE after full adjustment by potential confounders significantly increased in the individuals with ECG-LVH by any criteria of the SL voltage, CV, and CP (HR = 1.77, P &lt; 0.001) compared to those with no ECG-LVH. This association was also significant in individuals without any of obesity, dyslipidemia, and diabetes mellitus or those with systolic blood pressure (BP) &lt;120 mm Hg and diastolic BP &lt;80 mm Hg. Furthermore, ECG-LVH by each criteria provided the reclassification improvement for the CVE risk prediction model by the Framingham 10-year risk score (the net reclassification improvement = 0.17–0.22, each P value &lt; 0.010). CONCLUSIONS In the absence of hypertension, ECG-LVH parameters are associated with the increased risk of developed CVEs independent of the established risk factors and provide the additional prognostic value in an assessment of the CVE risk using the traditional risk factors.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1093/ajh/hpy055</identifier><identifier>PMID: 29659657</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>American journal of hypertension, 2018-07, Vol.31 (8), p.895-901</ispartof><rights>American Journal of Hypertension, Ltd 2018. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-785edca60104b71b51788c5f9f173d29774eab721f69dc85a30e8b09b0c8502a3</citedby><cites>FETCH-LOGICAL-c419t-785edca60104b71b51788c5f9f173d29774eab721f69dc85a30e8b09b0c8502a3</cites><orcidid>0000-0002-3520-3305</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29659657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Kentaro</creatorcontrib><creatorcontrib>Tanaka, Fumitaka</creatorcontrib><creatorcontrib>Onoda, Toshiyuki</creatorcontrib><creatorcontrib>Tanno, Kozo</creatorcontrib><creatorcontrib>Ohsawa, Masaki</creatorcontrib><creatorcontrib>Sakata, Kiyomi</creatorcontrib><creatorcontrib>Omama, Shinichi</creatorcontrib><creatorcontrib>Ogasawara, Kuniaki</creatorcontrib><creatorcontrib>Ishibashi, Yasuhiro</creatorcontrib><creatorcontrib>Itai, Kazuyoshi</creatorcontrib><creatorcontrib>Kuribayashi, Toru</creatorcontrib><creatorcontrib>Okayama, Akira</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>Iwate-Kenco Study Group</creatorcontrib><title>Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Abstract BACKGROUND The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals. METHODS A total of 4,927 non-hypertensive individuals ≥40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP). RESULTS During the average 9.8 ± 2.0 years of follow-up, 267 individuals (5.4%) had their first CVE. The hazard ratio (HR) for the incidence of CVE after full adjustment by potential confounders significantly increased in the individuals with ECG-LVH by any criteria of the SL voltage, CV, and CP (HR = 1.77, P &lt; 0.001) compared to those with no ECG-LVH. This association was also significant in individuals without any of obesity, dyslipidemia, and diabetes mellitus or those with systolic blood pressure (BP) &lt;120 mm Hg and diastolic BP &lt;80 mm Hg. Furthermore, ECG-LVH by each criteria provided the reclassification improvement for the CVE risk prediction model by the Framingham 10-year risk score (the net reclassification improvement = 0.17–0.22, each P value &lt; 0.010). CONCLUSIONS In the absence of hypertension, ECG-LVH parameters are associated with the increased risk of developed CVEs independent of the established risk factors and provide the additional prognostic value in an assessment of the CVE risk using the traditional risk factors.</description><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp90MFO3DAQBmCrApWF9tIHqHypVCGFHWfjOD6WFQWkFayqlmvkOBPWNLGDnSDlIXhnDAGOSJZG1nzzH35CvjE4YSBXS3W3W-76CTj_RBZMZiwRacr3yAIKyRMBOTsghyHcAUCW5-wzOUhlzuMTC_K49e7WujAYTW9UOyJ1DT1rUQ_eaeVr42696ndxu8FmoDdoB2_02CpPL6YefWT9bqLO0vWLflBh3v4x4T81lip65WwyW7TBPCBdu64brRmm5FQFrOnW9fFkMM5-IfuNagN-fZ1H5N_vs7_ri2RzfX65_rVJdMbkkIiCY61VDgyySrCKM1EUmjeyYWJVp1KIDFUlUtbkstYFVyvAogJZQfxAqlZH5Oec23t3P2IYys4EjW2rLLoxlCmkeQYFKyDS45lq70Lw2JS9N53yU8mgfK6_jPWXc_0Rf3_NHasO63f61ncEP2bgxv6joCebm5EJ</recordid><startdate>20180716</startdate><enddate>20180716</enddate><creator>Tanaka, Kentaro</creator><creator>Tanaka, Fumitaka</creator><creator>Onoda, Toshiyuki</creator><creator>Tanno, Kozo</creator><creator>Ohsawa, Masaki</creator><creator>Sakata, Kiyomi</creator><creator>Omama, Shinichi</creator><creator>Ogasawara, Kuniaki</creator><creator>Ishibashi, Yasuhiro</creator><creator>Itai, Kazuyoshi</creator><creator>Kuribayashi, Toru</creator><creator>Okayama, Akira</creator><creator>Nakamura, Motoyuki</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3520-3305</orcidid></search><sort><creationdate>20180716</creationdate><title>Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population</title><author>Tanaka, Kentaro ; Tanaka, Fumitaka ; Onoda, Toshiyuki ; Tanno, Kozo ; Ohsawa, Masaki ; Sakata, Kiyomi ; Omama, Shinichi ; Ogasawara, Kuniaki ; Ishibashi, Yasuhiro ; Itai, Kazuyoshi ; Kuribayashi, Toru ; Okayama, Akira ; Nakamura, Motoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-785edca60104b71b51788c5f9f173d29774eab721f69dc85a30e8b09b0c8502a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Kentaro</creatorcontrib><creatorcontrib>Tanaka, Fumitaka</creatorcontrib><creatorcontrib>Onoda, Toshiyuki</creatorcontrib><creatorcontrib>Tanno, Kozo</creatorcontrib><creatorcontrib>Ohsawa, Masaki</creatorcontrib><creatorcontrib>Sakata, Kiyomi</creatorcontrib><creatorcontrib>Omama, Shinichi</creatorcontrib><creatorcontrib>Ogasawara, Kuniaki</creatorcontrib><creatorcontrib>Ishibashi, Yasuhiro</creatorcontrib><creatorcontrib>Itai, Kazuyoshi</creatorcontrib><creatorcontrib>Kuribayashi, Toru</creatorcontrib><creatorcontrib>Okayama, Akira</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>Iwate-Kenco Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Kentaro</au><au>Tanaka, Fumitaka</au><au>Onoda, Toshiyuki</au><au>Tanno, Kozo</au><au>Ohsawa, Masaki</au><au>Sakata, Kiyomi</au><au>Omama, Shinichi</au><au>Ogasawara, Kuniaki</au><au>Ishibashi, Yasuhiro</au><au>Itai, Kazuyoshi</au><au>Kuribayashi, Toru</au><au>Okayama, Akira</au><au>Nakamura, Motoyuki</au><aucorp>Iwate-Kenco Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>2018-07-16</date><risdate>2018</risdate><volume>31</volume><issue>8</issue><spage>895</spage><epage>901</epage><pages>895-901</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><abstract>Abstract BACKGROUND The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals. METHODS A total of 4,927 non-hypertensive individuals ≥40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP). RESULTS During the average 9.8 ± 2.0 years of follow-up, 267 individuals (5.4%) had their first CVE. The hazard ratio (HR) for the incidence of CVE after full adjustment by potential confounders significantly increased in the individuals with ECG-LVH by any criteria of the SL voltage, CV, and CP (HR = 1.77, P &lt; 0.001) compared to those with no ECG-LVH. This association was also significant in individuals without any of obesity, dyslipidemia, and diabetes mellitus or those with systolic blood pressure (BP) &lt;120 mm Hg and diastolic BP &lt;80 mm Hg. 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title Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population
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