Effect of hyperoxidized guanine on DNA primer–template structures: Spiroiminodihydantoin leads to strand slippage

Oxidation of guanine in DNA can lead to mutagenic lesions such as 7-hydro-8-oxoguanine (oG). Upon further oxidation, a more mutagenic lesion, spirominodihydantoin (Sp), can occur. In this study, nuclear magnetic resonance (NMR) investigations were performed to determine the structural features of DN...

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Veröffentlicht in:	FEBS letters 2008-12, Vol.582 (30), p.4169-4175
Hauptverfasser:	Fenn, Dickson, Chi, Lai Man, Lam, Sik Lok
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2-dimethyl-2-silapentane-5-sulfonic acid 7-hydro-8-oxoguanine Base Sequence correlation spectroscopy COSY dATP dCTP DEAE deoxyadenosine triphosphate deoxycytidine triphosphate diethylaminoethyl DNA DNA Primers - chemistry DNA Replication double-quantum-filtered DQF DSS Guanine Guanosine - analogs & derivatives Guanosine - chemistry heteronuclear single quantum coherence spectroscopy high performance liquid chromatography HPLC HSQC MALDI mass spectrometry matrix-assisted laser desorption ionization Models, Chemical Molecular Structure Mutagenesis NaCl NaPi NMR NOE NOESY nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular nuclear Overhauser effect nuclear Overhauser effect spectroscopy one-dimensional Oxidation-Reduction Oxides - chemistry PAGE polyacrylamide gel electrophoresis sodium chloride sodium phosphate Spiro Compounds - chemistry Spiroiminodihydantoin Strand slippage Templates, Genetic Thermodynamics time-of-flight TOCSY TOF total correlation spectroscopy two-dimensional ultra-violet water suppression by gradient-tailored excitation WATERGATE
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