$Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions$

Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions

Several nitrofurans and nitroimidazoles have been widely used in veterinary medicine. Some of these compounds are breast carcinogens in rodents and their mechanism of action is hypothesized to be related to reactive metabolites generated by nitroreduction and/or via oxygen-dependent redox cycling. T...

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Veröffentlicht in:	Food and chemical toxicology 2009, Vol.47 (1), p.140-144
Hauptverfasser:	Bartel, L.C., Montalto de Mecca, M., Castro, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Carcinogens - chemistry Carcinogens - toxicity Chemical agents Female Food Contamination Hypoxanthine Mammary Glands, Animal - drug effects Mammary tissue Medical sciences Molecular Structure NADP Nitrofurans Nitrofurans - chemistry Nitrofurans - toxicity Nitroimidazoles Nitroimidazoles - chemistry Nitroimidazoles - toxicity Nitroreductases - metabolism Oxidation-Reduction Rats Rats, Sprague-Dawley Toxicology Tumors Xanthine-oxidoreductase
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