Efficient biocatalytic synthesis of nicotinic acid by recombinant nitrilase via high density culture

[Display omitted] •The nitrilase was constitutively expressed in E. coli.•The nitrilase activity was improved by 14.9-fold via high density culture.•The nicotinic acid synthesized by nitrilase was the highest level to date. The constitutively expression system for P. putida nitrilase was firstly con...

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Veröffentlicht in:	Bioresource technology 2018-07, Vol.260, p.427-431
Hauptverfasser:	Gong, Jin-Song, Zhang, Qiang, Gu, Bing-Chen, Dong, Ting-Ting, Li, Heng, Li, Hui, Lu, Zhen-Ming, Shi, Jin-Song, Xu, Zheng-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Fed-batch conversion High density culture Nicotinic acid Nitrilase
Online-Zugang:	Volltext
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