Silencing of casein kinase 2 inhibits PKC‑induced cell invasion by targeting MMP‑9 in MCF‑7 cells

Casein kinase 2 (CK2) is a serine/threonine protein kinase that has been considered to represent an important factor in mammary tumorigenesis. Increased expression of matrix metalloproteinase‑9 (MMP‑9) via nuclear factor‑κB (NF‑κB) activation has been demonstrated to promote breast cancer cell invas...

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Veröffentlicht in:	Molecular medicine reports 2018-06, Vol.17 (6), p.8397-8402
Hauptverfasser:	Kim, Jeong-Mi, Noh, Eun-Mi, Song, Hyun-Kyung, You, Yong-Ouk, Jung, Sung Hoo, Kim, Jong-Suk, Kwon, Kang-Beom, Lee, Young-Rae, Youn, Hyun Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Benzimidazoles Breast cancer c-Jun protein Cancer invasiveness Cancer research Casein Casein kinase II Cell cycle Cell division Development and progression Emodin Gelatinase B Health aspects Immunoglobulins Invasiveness JNK protein Kinases Matrix metalloproteinase Medical prognosis Metalloproteinase Metastasis Molecular modelling NF-κB protein Physiological aspects Polymerase chain reaction Proteases Protein expression Protein kinase C Protein kinases Protein-serine/threonine kinase Proteins Reverse transcription siRNA Studies Transcription factors Tumorigenesis
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