Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism

Abstract Astaxanthin is a powerful antioxidant that occurs naturally in a wide variety of living organisms. The aim of this study is to investigate the effect and the mechanism of astaxanthin on reactive oxygen species (ROS)-mediated apoptosis in dopaminergic SH-SY5Y cells. The treatment with DHA hy...

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Veröffentlicht in:	Brain research 2009-02, Vol.1254, p.18-27
Hauptverfasser:	Liu, Xuebo, Shibata, Takahiro, Hisaka, Shinsuke, Osawa, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Apoptosis - drug effects Astaxanthin Blotting, Western Cell Line Cell Survival - drug effects Chromatography, High Pressure Liquid Cytochromes c - metabolism DNA Fragmentation - drug effects Docosahexaenoic Acids - toxicity Dopamine - metabolism Humans Lipid Peroxides - toxicity Membrane Potential, Mitochondrial - drug effects Microscopy, Fluorescence Mitochondria - drug effects Mitochondria protection Neurology Neuronal apoptosis Neurons - drug effects Neurons - physiology Oxidopamine - toxicity Parkinson's disease Protein Carbonylation - drug effects Reactive oxygen specie Reactive Oxygen Species - metabolism Xanthophylls - pharmacology
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