Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features

A subset of melanomas carrying a B-Raf proto-oncogene, serine/threonine kinase gene (BRAF) V600E mutation, which is the most common targetable mutation in melanoma, arise in association with a melanocytic nevus that is also harboring a BRAF V600E mutation. The detailed histomorphologic characteristi...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 2018-08, Vol.79 (2), p.221-229
Hauptverfasser:	Kiuru, Maija, Tartar, Danielle M., Qi, Lihong, Chen, Danyang, Yu, Lan, Konia, Thomas, McPherson, John D., Murphy, William J., Fung, Maxwell A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult BRAF Cell Size dermatopathology Diagnosis, Differential Epidermis - pathology Female gene Gene Expression histomorphology Humans Immunohistochemistry Male Melanocytes - pathology melanocytic nevus melanoma Middle Aged Mutation Nevus - diagnosis Nevus, Pigmented - classification Nevus, Pigmented - genetics Nevus, Pigmented - pathology Proto-Oncogene Proteins B-raf - genetics Retrospective Studies Skin Neoplasms - classification Skin Neoplasms - genetics Skin Neoplasms - pathology
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