Estrogenicity of alkylphenols and alkylated non-phenolics in a rainbow trout ( Oncorhynchus mykiss) primary hepatocyte culture

Alkylphenols act as estrogen mimics by binding to and transactivating estrogen receptors (ERs) in fish. In the present study, activation of ER-mediated production of the estrogenic biomarker vitellogenin (vtg) in a primary culture of rainbow trout ( Oncorhynchus mykiss) hepatocytes was used to const...

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Veröffentlicht in:	Ecotoxicology and environmental safety 2008-10, Vol.71 (2), p.370-383
Hauptverfasser:	Tollefsen, K.-E., Eikvar, Sissel, Finne, Eivind Farmen, Fogelberg, Oscar, Gregersen, Inger Katharina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-estrogen Biomarkers Cells, Cultured Cytotoxicity Endocrine disrupters Estrogen mimics Estrogen receptor Estrogens - toxicity Fish Hepatocytes - drug effects Hepatocytes - metabolism Male Molecular Biology Oncorhynchus mykiss Phenols - toxicity Receptors, Estrogen Structure-Activity Relationship Vitellogenin Vitellogenins - metabolism Water Pollutants, Chemical - toxicity Xenestrogen
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