Metal-free C(sp2)–H functionalization of azoles: K2CO3/I2-mediated oxidation, imination, and amination

The direct C2−H oxidation and imination of a wide variety of azoles was achieved by using a commercially available simple K2CO3/I2 reagent combination. The iodinated azole adduct, produced via the in situ generation of N-heterocyclic carbene, is the key intermediate for C2−H oxidation, imination, an...

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Veröffentlicht in:	Organic & biomolecular chemistry 2018, Vol.16 (23), p.4243-4260
Hauptverfasser:	Das, Ranajit, Banerjee, Mainak, Rai, Rakesh Kumar, Karri, Ramesh, Gouriprasanna Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Aromatic compounds Azoles Heterocyclic compounds Oxidation Pharmacology Potassium carbonate Reagents Substrates
Online-Zugang:	Volltext
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