Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives

Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer chemotherapy. This valuable class of alkylating agent exerts its biological activity by binding to DNA, cross linking two strands, p...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-05, Vol.151, p.401-433
Hauptverfasser:	Singh, Rajesh K., Kumar, Sahil, Prasad, D.N., Bhardwaj, T.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADEPT Chlorambucil CNS targeted mustards Cyclophosphamide GDEPT Mechlorethamine Melphalan Peptide based mustards Steroidal mustards
Online-Zugang:	Volltext
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