Glucocorticoid pretreatment increases toxicity due to peroxides in alveolar epithelial-like cell lines

Abstract In previous experiments an increase in zinc-mediated toxicity was found after pretreatment of alveolar epithelial type II-like cells with glucocorticoids. In this work toxicity of two peroxides (tertiary butyl hydroperoxide [tBHP], hydrogene peroxide [HP]) was assessed in L2 and A549 cells...

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Veröffentlicht in:	Toxicology (Amsterdam) 2009-02, Vol.256 (1), p.48-52
Hauptverfasser:	Walther, Udo I, Stets, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 cells Algorithms Biological and medical sciences Butyl hydroperoxide Dexamethasone Dexamethasone - pharmacology Emergency Epithelial Cells - drug effects Glucocorticoids - pharmacology Glutathione - metabolism Glutathione Reductase - metabolism Humans Hydrogene peroxide L2 cells Medical sciences Oxidative Stress - drug effects Peroxides - toxicity Protein Synthesis Inhibitors - pharmacology Pulmonary Alveoli - cytology Pulmonary Alveoli - drug effects tert-Butylhydroperoxide - toxicity Toxicology
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