Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects

Impaired premorbid functioning prior to the onset of acute psychosis has frequently been noted in schizophrenia. This study examined retrospectively the premorbid status of patients in their first episode of psychosis in order to determine relationships with baseline symptoms, treatment response, an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Schizophrenia bulletin 2004-01, Vol.30 (2), p.265-278
Hauptverfasser: Strous, Rael D., Alvir, Jose Ma. J., Robinson, Delbert, Gal, Gilad, Sheitman, Brian, Chakos, Miranda, Lieberman, Jeffrey A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 278
container_issue 2
container_start_page 265
container_title Schizophrenia bulletin
container_volume 30
creator Strous, Rael D.
Alvir, Jose Ma. J.
Robinson, Delbert
Gal, Gilad
Sheitman, Brian
Chakos, Miranda
Lieberman, Jeffrey A.
description Impaired premorbid functioning prior to the onset of acute psychosis has frequently been noted in schizophrenia. This study examined retrospectively the premorbid status of patients in their first episode of psychosis in order to determine relationships with baseline symptoms, treatment response, and medication side effects. One hundred eleven schizophrenic and schizoaffective patients participating in a large prospective study of first episode schizophrenia were evaluated with the Premorbid Adjustment Scale (PAS). Premorbid functioning in males became progressively worse over time. Deficit state patients exhibited worse premorbid functioning. A third of patients exhibited sustained poor premorbid functioning. At various developmental stages, lower "sociability and withdrawal" scores correlated with increased time to treatment response, more severe negative symptoms, increased drug-induced parkinsonism, and deterioration of premorbid functioning. Various mean PAS scores predicted susceptibility to tardive dyskinesia. Our findings suggest that prior to acute psychosis onset there are certain behavioral precursors reflected in premorbid functioning that may predict subsequent illness manifestations. Measures of premorbid functioning indicate that disease pathogenesis is manifest, albeit more subtly, prior to presentation of first psychotic symptoms.
doi_str_mv 10.1093/oxfordjournals.schbul.a007077
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20247188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>614391453</sourcerecordid><originalsourceid>FETCH-LOGICAL-a527t-88711f27fc8462e428d1bbe95383eecd4806531e73307e573b9a4fee9604a9403</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEokPhFZCFVDY0g_8Sx5VY0KoFpCIQU9aW49wwrhI72E7F9OnxKIP4WbDywt-x7z1fUZwQvCZYstf-R-9Dd-vn4PQQ19Fs23lYa4wFFuJBsSKCVyURmDwsVrhq6lLUhB8VT2K8xZhwWdPHxRGpqJCYV6vi7nOA0YfWduhqdiZZ76z7hqxDG7O1937aBnBWn6EvMOj9LUoenesIg3WANrtxSn6Mp-gmgE4juJTBOHkX4RRp16GP0FmzBDe2A3TZ92BSfFo86vP48OxwHhdfry5vLt6X15_efbh4e13qPGEqm0YQ0lPRm4bXFDhtOtK2ICvWMADT8QbXFSMgGMMCKsFaqXkPIGvMteSYHRcvl3en4L_PEJMabTQwDNqBn6OimHJBmiaDL_4Bf1Wscn9MEl6x_0GUsopXnNMMvVkgE3yMAXo1BTvqsFMEq71C9bdCtShUB4U5__zwydyO0P1OH5xl4OQA6Gj00AftjI1_cJJKUu93f7VwetJqijujQ7JmgGjmkKUmFe9bxbCiiuYSfwIRxbvv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>614391453</pqid></control><display><type>article</type><title>Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>APA PsycARTICLES</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Strous, Rael D. ; Alvir, Jose Ma. J. ; Robinson, Delbert ; Gal, Gilad ; Sheitman, Brian ; Chakos, Miranda ; Lieberman, Jeffrey A.</creator><creatorcontrib>Strous, Rael D. ; Alvir, Jose Ma. J. ; Robinson, Delbert ; Gal, Gilad ; Sheitman, Brian ; Chakos, Miranda ; Lieberman, Jeffrey A.</creatorcontrib><description>Impaired premorbid functioning prior to the onset of acute psychosis has frequently been noted in schizophrenia. This study examined retrospectively the premorbid status of patients in their first episode of psychosis in order to determine relationships with baseline symptoms, treatment response, and medication side effects. One hundred eleven schizophrenic and schizoaffective patients participating in a large prospective study of first episode schizophrenia were evaluated with the Premorbid Adjustment Scale (PAS). Premorbid functioning in males became progressively worse over time. Deficit state patients exhibited worse premorbid functioning. A third of patients exhibited sustained poor premorbid functioning. At various developmental stages, lower "sociability and withdrawal" scores correlated with increased time to treatment response, more severe negative symptoms, increased drug-induced parkinsonism, and deterioration of premorbid functioning. Various mean PAS scores predicted susceptibility to tardive dyskinesia. Our findings suggest that prior to acute psychosis onset there are certain behavioral precursors reflected in premorbid functioning that may predict subsequent illness manifestations. Measures of premorbid functioning indicate that disease pathogenesis is manifest, albeit more subtly, prior to presentation of first psychotic symptoms.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/oxfordjournals.schbul.a007077</identifier><identifier>PMID: 15279045</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: National Institute of Mental Health</publisher><subject>Adjustment Disorders - epidemiology ; Adjustment Disorders - etiology ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Basal Ganglia Diseases - chemically induced ; Basal Ganglia Diseases - epidemiology ; Biological and medical sciences ; Brief Psychotic Disorder ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Drug Therapy ; Female ; Human ; Humans ; Inpatient ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Premorbidity ; Psychiatric Symptoms ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Psychoses ; Psychotic Disorders - complications ; Psychotic Disorders - drug therapy ; Retrospective Studies ; Schizoaffective Disorder ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - drug therapy ; Schizophrenia - epidemiology ; Sex Factors ; Side Effects (Drug) ; Social Alienation</subject><ispartof>Schizophrenia bulletin, 2004-01, Vol.30 (2), p.265-278</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Superintendent of Documents 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a527t-88711f27fc8462e428d1bbe95383eecd4806531e73307e573b9a4fee9604a9403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15929160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15279045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strous, Rael D.</creatorcontrib><creatorcontrib>Alvir, Jose Ma. J.</creatorcontrib><creatorcontrib>Robinson, Delbert</creatorcontrib><creatorcontrib>Gal, Gilad</creatorcontrib><creatorcontrib>Sheitman, Brian</creatorcontrib><creatorcontrib>Chakos, Miranda</creatorcontrib><creatorcontrib>Lieberman, Jeffrey A.</creatorcontrib><title>Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Impaired premorbid functioning prior to the onset of acute psychosis has frequently been noted in schizophrenia. This study examined retrospectively the premorbid status of patients in their first episode of psychosis in order to determine relationships with baseline symptoms, treatment response, and medication side effects. One hundred eleven schizophrenic and schizoaffective patients participating in a large prospective study of first episode schizophrenia were evaluated with the Premorbid Adjustment Scale (PAS). Premorbid functioning in males became progressively worse over time. Deficit state patients exhibited worse premorbid functioning. A third of patients exhibited sustained poor premorbid functioning. At various developmental stages, lower "sociability and withdrawal" scores correlated with increased time to treatment response, more severe negative symptoms, increased drug-induced parkinsonism, and deterioration of premorbid functioning. Various mean PAS scores predicted susceptibility to tardive dyskinesia. Our findings suggest that prior to acute psychosis onset there are certain behavioral precursors reflected in premorbid functioning that may predict subsequent illness manifestations. Measures of premorbid functioning indicate that disease pathogenesis is manifest, albeit more subtly, prior to presentation of first psychotic symptoms.</description><subject>Adjustment Disorders - epidemiology</subject><subject>Adjustment Disorders - etiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Basal Ganglia Diseases - chemically induced</subject><subject>Basal Ganglia Diseases - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Brief Psychotic Disorder</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Drug Therapy</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Inpatient</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Premorbidity</subject><subject>Psychiatric Symptoms</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychoses</subject><subject>Psychotic Disorders - complications</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Retrospective Studies</subject><subject>Schizoaffective Disorder</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - epidemiology</subject><subject>Sex Factors</subject><subject>Side Effects (Drug)</subject><subject>Social Alienation</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEokPhFZCFVDY0g_8Sx5VY0KoFpCIQU9aW49wwrhI72E7F9OnxKIP4WbDywt-x7z1fUZwQvCZYstf-R-9Dd-vn4PQQ19Fs23lYa4wFFuJBsSKCVyURmDwsVrhq6lLUhB8VT2K8xZhwWdPHxRGpqJCYV6vi7nOA0YfWduhqdiZZ76z7hqxDG7O1937aBnBWn6EvMOj9LUoenesIg3WANrtxSn6Mp-gmgE4juJTBOHkX4RRp16GP0FmzBDe2A3TZ92BSfFo86vP48OxwHhdfry5vLt6X15_efbh4e13qPGEqm0YQ0lPRm4bXFDhtOtK2ICvWMADT8QbXFSMgGMMCKsFaqXkPIGvMteSYHRcvl3en4L_PEJMabTQwDNqBn6OimHJBmiaDL_4Bf1Wscn9MEl6x_0GUsopXnNMMvVkgE3yMAXo1BTvqsFMEq71C9bdCtShUB4U5__zwydyO0P1OH5xl4OQA6Gj00AftjI1_cJJKUu93f7VwetJqijujQ7JmgGjmkKUmFe9bxbCiiuYSfwIRxbvv</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Strous, Rael D.</creator><creator>Alvir, Jose Ma. J.</creator><creator>Robinson, Delbert</creator><creator>Gal, Gilad</creator><creator>Sheitman, Brian</creator><creator>Chakos, Miranda</creator><creator>Lieberman, Jeffrey A.</creator><general>National Institute of Mental Health</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20040101</creationdate><title>Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects</title><author>Strous, Rael D. ; Alvir, Jose Ma. J. ; Robinson, Delbert ; Gal, Gilad ; Sheitman, Brian ; Chakos, Miranda ; Lieberman, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a527t-88711f27fc8462e428d1bbe95383eecd4806531e73307e573b9a4fee9604a9403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adjustment Disorders - epidemiology</topic><topic>Adjustment Disorders - etiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Basal Ganglia Diseases - chemically induced</topic><topic>Basal Ganglia Diseases - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Brief Psychotic Disorder</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Drug Therapy</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Inpatient</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Premorbidity</topic><topic>Psychiatric Symptoms</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychoses</topic><topic>Psychotic Disorders - complications</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Retrospective Studies</topic><topic>Schizoaffective Disorder</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - epidemiology</topic><topic>Sex Factors</topic><topic>Side Effects (Drug)</topic><topic>Social Alienation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strous, Rael D.</creatorcontrib><creatorcontrib>Alvir, Jose Ma. J.</creatorcontrib><creatorcontrib>Robinson, Delbert</creatorcontrib><creatorcontrib>Gal, Gilad</creatorcontrib><creatorcontrib>Sheitman, Brian</creatorcontrib><creatorcontrib>Chakos, Miranda</creatorcontrib><creatorcontrib>Lieberman, Jeffrey A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Access via APA PsycArticles® (ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strous, Rael D.</au><au>Alvir, Jose Ma. J.</au><au>Robinson, Delbert</au><au>Gal, Gilad</au><au>Sheitman, Brian</au><au>Chakos, Miranda</au><au>Lieberman, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>30</volume><issue>2</issue><spage>265</spage><epage>278</epage><pages>265-278</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>Impaired premorbid functioning prior to the onset of acute psychosis has frequently been noted in schizophrenia. This study examined retrospectively the premorbid status of patients in their first episode of psychosis in order to determine relationships with baseline symptoms, treatment response, and medication side effects. One hundred eleven schizophrenic and schizoaffective patients participating in a large prospective study of first episode schizophrenia were evaluated with the Premorbid Adjustment Scale (PAS). Premorbid functioning in males became progressively worse over time. Deficit state patients exhibited worse premorbid functioning. A third of patients exhibited sustained poor premorbid functioning. At various developmental stages, lower "sociability and withdrawal" scores correlated with increased time to treatment response, more severe negative symptoms, increased drug-induced parkinsonism, and deterioration of premorbid functioning. Various mean PAS scores predicted susceptibility to tardive dyskinesia. Our findings suggest that prior to acute psychosis onset there are certain behavioral precursors reflected in premorbid functioning that may predict subsequent illness manifestations. Measures of premorbid functioning indicate that disease pathogenesis is manifest, albeit more subtly, prior to presentation of first psychotic symptoms.</abstract><cop>Oxford</cop><pub>National Institute of Mental Health</pub><pmid>15279045</pmid><doi>10.1093/oxfordjournals.schbul.a007077</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0586-7614
ispartof Schizophrenia bulletin, 2004-01, Vol.30 (2), p.265-278
issn 0586-7614
1745-1701
language eng
recordid cdi_proquest_miscellaneous_20247188
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; APA PsycARTICLES; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Adjustment Disorders - epidemiology
Adjustment Disorders - etiology
Adolescent
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Basal Ganglia Diseases - chemically induced
Basal Ganglia Diseases - epidemiology
Biological and medical sciences
Brief Psychotic Disorder
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Drug Therapy
Female
Human
Humans
Inpatient
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Premorbidity
Psychiatric Symptoms
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychoses
Psychotic Disorders - complications
Psychotic Disorders - drug therapy
Retrospective Studies
Schizoaffective Disorder
Schizophrenia
Schizophrenia - complications
Schizophrenia - drug therapy
Schizophrenia - epidemiology
Sex Factors
Side Effects (Drug)
Social Alienation
title Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A50%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Premorbid%20Functioning%20in%20Schizophrenia:%20Relation%20to%20Baseline%20Symptoms,%20Treatment%20Response,%20and%20Medication%20Side%20Effects&rft.jtitle=Schizophrenia%20bulletin&rft.au=Strous,%20Rael%20D.&rft.date=2004-01-01&rft.volume=30&rft.issue=2&rft.spage=265&rft.epage=278&rft.pages=265-278&rft.issn=0586-7614&rft.eissn=1745-1701&rft.coden=SCZBB3&rft_id=info:doi/10.1093/oxfordjournals.schbul.a007077&rft_dat=%3Cproquest_cross%3E614391453%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=614391453&rft_id=info:pmid/15279045&rfr_iscdi=true