Identification of ROBO1 as a Novel Hepatocellular Carcinoma Antigen and a Potential Therapeutic and Diagnostic Target

Purpose: Hepatocellular carcinoma is the most common primary malignancy of the liver and accounts for as many as one million deaths annually worldwide. The present study was done to identify new transmembrane molecules for antibody therapy in hepatocellular carcinoma. Experimental Design: Gene expre...

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Veröffentlicht in:	Clinical cancer research 2006-06, Vol.12 (11), p.3257-3264
Hauptverfasser:	ITO, Hirotaka, FUNAHASHI, Shin-Ichi, IWANARI, Hiroko, NAKAJIMA, Atsushi, MAKUUCHI, Masatoshi, FUKAYAMA, Masashi, HIRATA, Yuichi, HAMAKUBO, Takao, KODAMA, Tatsuhiko, TSUCHIYA, Masayuki, ABURATANI, Hiroyuki, YAMAUCHI, Naoko, SHIBAHARA, Junji, MIDORIKAWA, Yutaka, KAWAI, Shigeto, KINOSHITA, Yasuko, WATANABE, Akira, HIPPO, Yoshitaka, OHTOMO, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology antibody therapy Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics CDC activity Cell Line, Tumor Cell Proliferation - drug effects Chlorocebus aethiops COS Cells Cytotoxicity Tests, Immunologic DNA microarray Drosophila Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Gene Expression Regulation, Neoplastic hepatocellular carcinoma Humans Immunohistochemistry Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - blood Nerve Tissue Proteins - genetics Pharmacology. Drug treatments Protein Structure, Tertiary Receptors, Immunologic - biosynthesis Receptors, Immunologic - blood Receptors, Immunologic - genetics Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis ROBO1 Roundabout Proteins shed antigen soluble ROBO1 tumor marker Tumors Up-Regulation - genetics
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