Interleukin (IL) 36 gamma induces mucin 5AC, oligomeric mucus/gel-forming expression via IL-36 receptor–extracellular signal regulated kinase 1 and 2, and p38–nuclear factor kappa-light-chain-enhancer of activated B cells in human airway epithelial cells

Background: Mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) expression is significantly increased in allergic and inflammatory airway diseases. Interleukin (IL) 36 gamma is predominantly expressed in airway epithelial cells and plays an important role in innate and adaptive immune responses. IL-36...

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Veröffentlicht in:	American journal of rhinology & allergy 2018-03, Vol.32 (2), p.87-93
Hauptverfasser:	Bae, Chang Hoon, Choi, Yoon Seok, Na, Hyung Gyun, Song, Si-Youn, Kim, Yong-Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression - drug effects Humans Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-1 - physiology Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mucin 5AC - biosynthesis Mucin 5AC - genetics Mucin 5AC - metabolism Nasal Mucosa - cytology NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Phosphorylation - drug effects Receptors, Interleukin - antagonists & inhibitors Receptors, Interleukin - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - drug effects
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