Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2–Ub) 1 . Ubiquitin ligases (E3s) of the ‘really interesting new gene’ (RING) class recruit E2–Ub via their RING doma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2018-04, Vol.556 (7701), p.381-385
Hauptverfasser:	Pao, Kuan-Chuan, Wood, Nicola T., Knebel, Axel, Rafie, Karim, Stanley, Mathew, Mabbitt, Peter D., Sundaramoorthy, Ramasubramanian, Hofmann, Kay, van Aalten, Daan M. F., Virdee, Satpal
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/458/582 631/45/173 631/535/1266 631/92/96 Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Amino acids Analysis Biocatalysis Catalysis Cell Line, Tumor Criminal investigation Crystallography Crystallography, X-Ray Cysteine Cysteine - metabolism Cystine Enzymes Esterification Eukaryotes Genes HEK293 Cells Homology Humanities and Social Sciences Humans Intermediates Letter Ligases Lysine Lysine - metabolism Models, Molecular multidisciplinary Neurons Post-translation Post-translational modifications Protein Domains Proteins Proteomics Residues Resveratrol Science Science (multidisciplinary) Scientific imaging Selectivity Serine Serine - metabolism Substrate Specificity Substrates Threonine Threonine - metabolism Ubiquitin Ubiquitin - metabolism Ubiquitin-conjugating enzyme Ubiquitin-proteasome system Ubiquitin-protein ligase Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!