Reactive oxygen species impact on sperm DNA and its role in male infertility

Summary Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility. Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative stress (OS), which in turn can lead to nuclear and mitochondrial DNA damage, telomere shortening, epigenetic alt...

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Veröffentlicht in:	Andrologia 2018-10, Vol.50 (8), p.e13012-n/a
Hauptverfasser:	Bui, A. D., Sharma, R., Henkel, R., Agarwal, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apoptosis Deoxyribonucleic acid DNA DNA Damage DNA, Mitochondrial - metabolism epigenetics Humans Infertility Infertility, Male - etiology Infertility, Male - metabolism Male mitochondria Mitochondrial DNA Oxidative Stress Reactive oxygen species Reactive Oxygen Species - metabolism spermatozoa Spermatozoa - metabolism Telomere Homeostasis
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