Oesophageal diameter is associated with severity but not progression of systemic sclerosis‐associated interstitial lung disease
ABSTRACT Background and objective It is unknown whether oesophageal disease is associated with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) severity, progression or mortality. Methods High‐resolution computed tomography (HRCT) scans from 145 SSc‐ILD patients were scored for fibr...
Gespeichert in:
| Veröffentlicht in: | Respirology (Carlton, Vic.) Vic.), 2018-10, Vol.23 (10), p.921-926 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 926 |
|---|---|
| container_issue | 10 |
| container_start_page | 921 |
| container_title | Respirology (Carlton, Vic.) |
| container_volume | 23 |
| creator | Winstone, Tiffany A. Hague, Cameron J. Soon, Jeanette Sulaiman, Nada Murphy, Darra Leipsic, Jonathon Dunne, James V. Wilcox, Pearce G. Ryerson, Christopher J. |
| description | ABSTRACT
Background and objective
It is unknown whether oesophageal disease is associated with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) severity, progression or mortality.
Methods
High‐resolution computed tomography (HRCT) scans from 145 SSc‐ILD patients were scored for fibrosis score, oesophageal diameter and presence of hiatal hernia. Fibrosis asymmetry was calculated as: (most affected side − least affected side)/(most affected side + least affected side). Mixed effects models were used for repeated measures analyses.
Results
Mean fibrosis score was 8.6%, and most patients had mild‐to‐moderate physiological impairment. Every 1 cm increase in oesophageal diameter was associated with 1.8% higher fibrosis score and 5.5% lower forced vital capacity (FVC; P ≤ 0.001 for unadjusted and adjusted analyses). Patients with hiatal hernia had 3.9% higher fibrosis score, with persistent differences on adjusted analysis (P = 0.001). Oesophageal diameter predicted worsening fibrosis score over the subsequent year (P = 0.02), but not when adjusting for baseline fibrosis score (P = 0.16). Oesophageal diameter was independently associated with mortality (P = 0.001). Oesophageal diameter was not associated with asymmetric disease or radiological features of gross aspiration.
Conclusion
Oesophageal diameter and hiatal hernia are independently associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetric disease. Oesophageal disease is unlikely to be a significant driver of ILD progression in SSc.
We used a large cohort of patients with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) to conduct the most comprehensive study to date evaluating the association of oesophageal measures with progression and mortality of SSc‐ILD. We show that oesophageal disease is associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetry.
See related Editorial |
| doi_str_mv | 10.1111/resp.13309 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2024469886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2024469886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3939-7bd7cb6d7c7c176d23957c07996dc868a4fa3544f97dc7013f66ef0f33884fa33</originalsourceid><addsrcrecordid>eNp9kc1qFTEUx0NR2lrd9AFKwI0I0yaT3HwsS6kfUKhYXYfczJnblJnJNSdjuTt9A5_RJzHXW6W4MIvkQH78zjn8CTnm7JTXc5YB16dcCGb3yCGXkjXcSPGk1qIVjdbWHpBniHeMMbFgi31y0FolK6MPyfdrwLS-9SvwA-2iH6FAphGpR0wh-gIdvY_lliJ8hRzLhi7nQqdU6DqnVe2MMU009RQ3WGCMgWIYICeM-PPbj0eSOFUxllhibTTM06p2Q_AIz8nT3g8ILx7eI_L5zeWni3fN1fXb9xfnV00QVthGLzsdlqpeOnCtulbYhQ6sLqe6YJTxsvdiIWVvdRc046JXCnrWC2HM9ksckVc7bx38ywxY3BgxwDD4CdKMrmWtlMoaoyr68h_0Ls15qtO5ljPLuGHCVOr1jgp1XczQu3WOo88bx5nbBuO2wbjfwVT45EE5L0fo_qJ_kqgA3wH3cYDNf1Tu4-XNh530F5KunG4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2109018038</pqid></control><display><type>article</type><title>Oesophageal diameter is associated with severity but not progression of systemic sclerosis‐associated interstitial lung disease</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Winstone, Tiffany A. ; Hague, Cameron J. ; Soon, Jeanette ; Sulaiman, Nada ; Murphy, Darra ; Leipsic, Jonathon ; Dunne, James V. ; Wilcox, Pearce G. ; Ryerson, Christopher J.</creator><creatorcontrib>Winstone, Tiffany A. ; Hague, Cameron J. ; Soon, Jeanette ; Sulaiman, Nada ; Murphy, Darra ; Leipsic, Jonathon ; Dunne, James V. ; Wilcox, Pearce G. ; Ryerson, Christopher J.</creatorcontrib><description>ABSTRACT
Background and objective
It is unknown whether oesophageal disease is associated with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) severity, progression or mortality.
Methods
High‐resolution computed tomography (HRCT) scans from 145 SSc‐ILD patients were scored for fibrosis score, oesophageal diameter and presence of hiatal hernia. Fibrosis asymmetry was calculated as: (most affected side − least affected side)/(most affected side + least affected side). Mixed effects models were used for repeated measures analyses.
Results
Mean fibrosis score was 8.6%, and most patients had mild‐to‐moderate physiological impairment. Every 1 cm increase in oesophageal diameter was associated with 1.8% higher fibrosis score and 5.5% lower forced vital capacity (FVC; P ≤ 0.001 for unadjusted and adjusted analyses). Patients with hiatal hernia had 3.9% higher fibrosis score, with persistent differences on adjusted analysis (P = 0.001). Oesophageal diameter predicted worsening fibrosis score over the subsequent year (P = 0.02), but not when adjusting for baseline fibrosis score (P = 0.16). Oesophageal diameter was independently associated with mortality (P = 0.001). Oesophageal diameter was not associated with asymmetric disease or radiological features of gross aspiration.
Conclusion
Oesophageal diameter and hiatal hernia are independently associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetric disease. Oesophageal disease is unlikely to be a significant driver of ILD progression in SSc.
We used a large cohort of patients with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) to conduct the most comprehensive study to date evaluating the association of oesophageal measures with progression and mortality of SSc‐ILD. We show that oesophageal disease is associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetry.
See related Editorial</description><identifier>ISSN: 1323-7799</identifier><identifier>EISSN: 1440-1843</identifier><identifier>DOI: 10.1111/resp.13309</identifier><identifier>PMID: 29641847</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Computed tomography ; Disease Progression ; Esophagus ; Esophagus - diagnostic imaging ; Esophagus - pathology ; Female ; Fibrosis ; fibrosis score ; Hernia ; Hernia, Hiatal - complications ; Hernia, Hiatal - diagnostic imaging ; Hernias ; Humans ; interstitial lung disease ; Lung diseases ; Lung Diseases, Interstitial - etiology ; Lung Diseases, Interstitial - physiopathology ; Male ; Middle Aged ; Mortality ; oesophageal diameter ; oesophageal disease ; Organ Size ; Pulmonary Fibrosis - complications ; Pulmonary Fibrosis - diagnostic imaging ; Pulmonary Fibrosis - physiopathology ; Respiratory diseases ; Scleroderma ; Scleroderma, Systemic - complications ; Severity of Illness Index ; Systemic sclerosis ; Tomography, X-Ray Computed ; Vital Capacity</subject><ispartof>Respirology (Carlton, Vic.), 2018-10, Vol.23 (10), p.921-926</ispartof><rights>2018 Asian Pacific Society of Respirology</rights><rights>2018 Asian Pacific Society of Respirology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-7bd7cb6d7c7c176d23957c07996dc868a4fa3544f97dc7013f66ef0f33884fa33</citedby><cites>FETCH-LOGICAL-c3939-7bd7cb6d7c7c176d23957c07996dc868a4fa3544f97dc7013f66ef0f33884fa33</cites><orcidid>0000-0001-8309-7191 ; 0000-0003-1049-393X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fresp.13309$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fresp.13309$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29641847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winstone, Tiffany A.</creatorcontrib><creatorcontrib>Hague, Cameron J.</creatorcontrib><creatorcontrib>Soon, Jeanette</creatorcontrib><creatorcontrib>Sulaiman, Nada</creatorcontrib><creatorcontrib>Murphy, Darra</creatorcontrib><creatorcontrib>Leipsic, Jonathon</creatorcontrib><creatorcontrib>Dunne, James V.</creatorcontrib><creatorcontrib>Wilcox, Pearce G.</creatorcontrib><creatorcontrib>Ryerson, Christopher J.</creatorcontrib><title>Oesophageal diameter is associated with severity but not progression of systemic sclerosis‐associated interstitial lung disease</title><title>Respirology (Carlton, Vic.)</title><addtitle>Respirology</addtitle><description>ABSTRACT
Background and objective
It is unknown whether oesophageal disease is associated with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) severity, progression or mortality.
Methods
High‐resolution computed tomography (HRCT) scans from 145 SSc‐ILD patients were scored for fibrosis score, oesophageal diameter and presence of hiatal hernia. Fibrosis asymmetry was calculated as: (most affected side − least affected side)/(most affected side + least affected side). Mixed effects models were used for repeated measures analyses.
Results
Mean fibrosis score was 8.6%, and most patients had mild‐to‐moderate physiological impairment. Every 1 cm increase in oesophageal diameter was associated with 1.8% higher fibrosis score and 5.5% lower forced vital capacity (FVC; P ≤ 0.001 for unadjusted and adjusted analyses). Patients with hiatal hernia had 3.9% higher fibrosis score, with persistent differences on adjusted analysis (P = 0.001). Oesophageal diameter predicted worsening fibrosis score over the subsequent year (P = 0.02), but not when adjusting for baseline fibrosis score (P = 0.16). Oesophageal diameter was independently associated with mortality (P = 0.001). Oesophageal diameter was not associated with asymmetric disease or radiological features of gross aspiration.
Conclusion
Oesophageal diameter and hiatal hernia are independently associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetric disease. Oesophageal disease is unlikely to be a significant driver of ILD progression in SSc.
We used a large cohort of patients with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) to conduct the most comprehensive study to date evaluating the association of oesophageal measures with progression and mortality of SSc‐ILD. We show that oesophageal disease is associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetry.
See related Editorial</description><subject>Adult</subject><subject>Aged</subject><subject>Computed tomography</subject><subject>Disease Progression</subject><subject>Esophagus</subject><subject>Esophagus - diagnostic imaging</subject><subject>Esophagus - pathology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>fibrosis score</subject><subject>Hernia</subject><subject>Hernia, Hiatal - complications</subject><subject>Hernia, Hiatal - diagnostic imaging</subject><subject>Hernias</subject><subject>Humans</subject><subject>interstitial lung disease</subject><subject>Lung diseases</subject><subject>Lung Diseases, Interstitial - etiology</subject><subject>Lung Diseases, Interstitial - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>oesophageal diameter</subject><subject>oesophageal disease</subject><subject>Organ Size</subject><subject>Pulmonary Fibrosis - complications</subject><subject>Pulmonary Fibrosis - diagnostic imaging</subject><subject>Pulmonary Fibrosis - physiopathology</subject><subject>Respiratory diseases</subject><subject>Scleroderma</subject><subject>Scleroderma, Systemic - complications</subject><subject>Severity of Illness Index</subject><subject>Systemic sclerosis</subject><subject>Tomography, X-Ray Computed</subject><subject>Vital Capacity</subject><issn>1323-7799</issn><issn>1440-1843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1qFTEUx0NR2lrd9AFKwI0I0yaT3HwsS6kfUKhYXYfczJnblJnJNSdjuTt9A5_RJzHXW6W4MIvkQH78zjn8CTnm7JTXc5YB16dcCGb3yCGXkjXcSPGk1qIVjdbWHpBniHeMMbFgi31y0FolK6MPyfdrwLS-9SvwA-2iH6FAphGpR0wh-gIdvY_lliJ8hRzLhi7nQqdU6DqnVe2MMU009RQ3WGCMgWIYICeM-PPbj0eSOFUxllhibTTM06p2Q_AIz8nT3g8ILx7eI_L5zeWni3fN1fXb9xfnV00QVthGLzsdlqpeOnCtulbYhQ6sLqe6YJTxsvdiIWVvdRc046JXCnrWC2HM9ksckVc7bx38ywxY3BgxwDD4CdKMrmWtlMoaoyr68h_0Ls15qtO5ljPLuGHCVOr1jgp1XczQu3WOo88bx5nbBuO2wbjfwVT45EE5L0fo_qJ_kqgA3wH3cYDNf1Tu4-XNh530F5KunG4</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Winstone, Tiffany A.</creator><creator>Hague, Cameron J.</creator><creator>Soon, Jeanette</creator><creator>Sulaiman, Nada</creator><creator>Murphy, Darra</creator><creator>Leipsic, Jonathon</creator><creator>Dunne, James V.</creator><creator>Wilcox, Pearce G.</creator><creator>Ryerson, Christopher J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8309-7191</orcidid><orcidid>https://orcid.org/0000-0003-1049-393X</orcidid></search><sort><creationdate>201810</creationdate><title>Oesophageal diameter is associated with severity but not progression of systemic sclerosis‐associated interstitial lung disease</title><author>Winstone, Tiffany A. ; Hague, Cameron J. ; Soon, Jeanette ; Sulaiman, Nada ; Murphy, Darra ; Leipsic, Jonathon ; Dunne, James V. ; Wilcox, Pearce G. ; Ryerson, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-7bd7cb6d7c7c176d23957c07996dc868a4fa3544f97dc7013f66ef0f33884fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Computed tomography</topic><topic>Disease Progression</topic><topic>Esophagus</topic><topic>Esophagus - diagnostic imaging</topic><topic>Esophagus - pathology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>fibrosis score</topic><topic>Hernia</topic><topic>Hernia, Hiatal - complications</topic><topic>Hernia, Hiatal - diagnostic imaging</topic><topic>Hernias</topic><topic>Humans</topic><topic>interstitial lung disease</topic><topic>Lung diseases</topic><topic>Lung Diseases, Interstitial - etiology</topic><topic>Lung Diseases, Interstitial - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>oesophageal diameter</topic><topic>oesophageal disease</topic><topic>Organ Size</topic><topic>Pulmonary Fibrosis - complications</topic><topic>Pulmonary Fibrosis - diagnostic imaging</topic><topic>Pulmonary Fibrosis - physiopathology</topic><topic>Respiratory diseases</topic><topic>Scleroderma</topic><topic>Scleroderma, Systemic - complications</topic><topic>Severity of Illness Index</topic><topic>Systemic sclerosis</topic><topic>Tomography, X-Ray Computed</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winstone, Tiffany A.</creatorcontrib><creatorcontrib>Hague, Cameron J.</creatorcontrib><creatorcontrib>Soon, Jeanette</creatorcontrib><creatorcontrib>Sulaiman, Nada</creatorcontrib><creatorcontrib>Murphy, Darra</creatorcontrib><creatorcontrib>Leipsic, Jonathon</creatorcontrib><creatorcontrib>Dunne, James V.</creatorcontrib><creatorcontrib>Wilcox, Pearce G.</creatorcontrib><creatorcontrib>Ryerson, Christopher J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Respirology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winstone, Tiffany A.</au><au>Hague, Cameron J.</au><au>Soon, Jeanette</au><au>Sulaiman, Nada</au><au>Murphy, Darra</au><au>Leipsic, Jonathon</au><au>Dunne, James V.</au><au>Wilcox, Pearce G.</au><au>Ryerson, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oesophageal diameter is associated with severity but not progression of systemic sclerosis‐associated interstitial lung disease</atitle><jtitle>Respirology (Carlton, Vic.)</jtitle><addtitle>Respirology</addtitle><date>2018-10</date><risdate>2018</risdate><volume>23</volume><issue>10</issue><spage>921</spage><epage>926</epage><pages>921-926</pages><issn>1323-7799</issn><eissn>1440-1843</eissn><abstract>ABSTRACT
Background and objective
It is unknown whether oesophageal disease is associated with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) severity, progression or mortality.
Methods
High‐resolution computed tomography (HRCT) scans from 145 SSc‐ILD patients were scored for fibrosis score, oesophageal diameter and presence of hiatal hernia. Fibrosis asymmetry was calculated as: (most affected side − least affected side)/(most affected side + least affected side). Mixed effects models were used for repeated measures analyses.
Results
Mean fibrosis score was 8.6%, and most patients had mild‐to‐moderate physiological impairment. Every 1 cm increase in oesophageal diameter was associated with 1.8% higher fibrosis score and 5.5% lower forced vital capacity (FVC; P ≤ 0.001 for unadjusted and adjusted analyses). Patients with hiatal hernia had 3.9% higher fibrosis score, with persistent differences on adjusted analysis (P = 0.001). Oesophageal diameter predicted worsening fibrosis score over the subsequent year (P = 0.02), but not when adjusting for baseline fibrosis score (P = 0.16). Oesophageal diameter was independently associated with mortality (P = 0.001). Oesophageal diameter was not associated with asymmetric disease or radiological features of gross aspiration.
Conclusion
Oesophageal diameter and hiatal hernia are independently associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetric disease. Oesophageal disease is unlikely to be a significant driver of ILD progression in SSc.
We used a large cohort of patients with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) to conduct the most comprehensive study to date evaluating the association of oesophageal measures with progression and mortality of SSc‐ILD. We show that oesophageal disease is associated with SSc‐ILD severity and mortality, but not with ILD progression or asymmetry.
See related Editorial</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>29641847</pmid><doi>10.1111/resp.13309</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8309-7191</orcidid><orcidid>https://orcid.org/0000-0003-1049-393X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1323-7799 |
| ispartof | Respirology (Carlton, Vic.), 2018-10, Vol.23 (10), p.921-926 |
| issn | 1323-7799 1440-1843 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2024469886 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Computed tomography Disease Progression Esophagus Esophagus - diagnostic imaging Esophagus - pathology Female Fibrosis fibrosis score Hernia Hernia, Hiatal - complications Hernia, Hiatal - diagnostic imaging Hernias Humans interstitial lung disease Lung diseases Lung Diseases, Interstitial - etiology Lung Diseases, Interstitial - physiopathology Male Middle Aged Mortality oesophageal diameter oesophageal disease Organ Size Pulmonary Fibrosis - complications Pulmonary Fibrosis - diagnostic imaging Pulmonary Fibrosis - physiopathology Respiratory diseases Scleroderma Scleroderma, Systemic - complications Severity of Illness Index Systemic sclerosis Tomography, X-Ray Computed Vital Capacity |
| title | Oesophageal diameter is associated with severity but not progression of systemic sclerosis‐associated interstitial lung disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T02%3A31%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oesophageal%20diameter%20is%20associated%20with%20severity%20but%20not%20progression%20of%20systemic%20sclerosis%E2%80%90associated%20interstitial%20lung%20disease&rft.jtitle=Respirology%20(Carlton,%20Vic.)&rft.au=Winstone,%20Tiffany%20A.&rft.date=2018-10&rft.volume=23&rft.issue=10&rft.spage=921&rft.epage=926&rft.pages=921-926&rft.issn=1323-7799&rft.eissn=1440-1843&rft_id=info:doi/10.1111/resp.13309&rft_dat=%3Cproquest_cross%3E2024469886%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2109018038&rft_id=info:pmid/29641847&rfr_iscdi=true |