In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey

Hepatic organic anion-transporting polypeptides (OATP) 1B1 and 1B3 are clinically relevant transporters associated with significant drug–drug interactions (DDIs) and safety concerns. Given that OATP1Bs in cynomolgus monkey share >90% degree of gene and amino acid sequence homology with human orth...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2018-06, Vol.365 (3), p.688-699
Hauptverfasser:	Ufuk, Ayşe, Kosa, Rachel E., Gao, Hongying, Bi, Yi-An, Modi, Sweta, Gates, Dana, Rodrigues, A. David, Tremaine, Larry M., Varma, Manthena V.S., Houston, J. Brian, Galetin, Aleksandra
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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