Dose- and time-dependent estradiol modulation of morphine antinociception in adult female rats

Abstract To clarify the activational role of ovarian hormones on pain and analgesia, the present study determined whether estradiol (E2) modulation of nociception and morphine antinociception in adult female rats depends on (1) the dose of E2 and (2) the interval between E2 treatment and nociceptive...

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Veröffentlicht in:	European journal of pain 2008-05, Vol.12 (4), p.472-479
Hauptverfasser:	Craft, Rebecca M, Ulibarri, Catherine, Leitl, Michael D, Sumner, Jean E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics, Opioid - pharmacology Anesthesia & Perioperative Care Animals Body Weight Dose-Response Relationship, Drug Drug Interactions Estradiol - pharmacology Estrogen Estrous Cycle - drug effects Estrous Cycle - physiology Female Lordosis Male Morphine - pharmacology Nociceptors - drug effects Nociceptors - physiology Organ Size Ovariectomy Pain Pain Medicine Pain Threshold - drug effects Pain Threshold - physiology Rats Rats, Sprague-Dawley Sexual Behavior, Animal - drug effects Sexual Behavior, Animal - physiology Uterus Uterus - anatomy & histology Vagina - cytology
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