Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu

Elongation factor Tu (EF-Tu), the protein responsible for delivering aminoacyl-tRNAs (aa-tRNAs) to ribosomal A site during translation, belongs to the group of guanosine-nucleotide (GTP/GDP) binding proteins. Its active ‘on’-state corresponds to the GTP-bound form, while the inactive ‘off’-state cor...

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Veröffentlicht in:	Biochimica et biophysica acta 2008-12, Vol.1784 (12), p.1908-1917
Hauptverfasser:	Grigorenko, B.L., Shadrina, M.S., Topol, I.A., Collins, J.R., Nemukhin, A.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Catalysis EF-Tu protein Enzymatic mechanism GTP hydrolysis Guanosine Diphosphate - chemistry Guanosine Diphosphate - metabolism Guanosine Triphosphate - chemistry Guanosine Triphosphate - metabolism Hydrolysis Models, Chemical Molecular modeling Peptide Elongation Factor Tu - chemistry Peptide Elongation Factor Tu - metabolism Ribosomes - chemistry Ribosomes - metabolism RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - metabolism Thermus thermophilus - enzymology
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