Stemphones, Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Aspergillus sp. FKI-2136
A fungal strain FKI-2136 identified as genus Aspergillus was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D...
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| Veröffentlicht in: | Journal of antibiotics 2005-11, Vol.58 (11), p.695-703 |
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| container_title | Journal of antibiotics |
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| creator | Koyama, Nobuhiro Nagahiro, Tomoko Yamaguchi, Yuichi Masuma, Rokuro Tomoda, Hiroshi Ōmura, Satoshi |
| description | A fungal strain FKI-2136 identified as genus
Aspergillus
was found to produce potentiators of imipenem activity against methicillin-resistant
Staphylococcus aureus
(MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. These compounds have a common tetracyclic quinone skeleton. Stemphone C potentiated imipenem activity against the MRSA 512 fold by decreasing MIC value of imipenem from 16 µg/ml to 0.03 µg/ml. |
| doi_str_mv | 10.1038/ja.2005.95 |
| format | Article |
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Aspergillus
was found to produce potentiators of imipenem activity against methicillin-resistant
Staphylococcus aureus
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Aspergillus
was found to produce potentiators of imipenem activity against methicillin-resistant
Staphylococcus aureus
(MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. These compounds have a common tetracyclic quinone skeleton. Stemphone C potentiated imipenem activity against the MRSA 512 fold by decreasing MIC value of imipenem from 16 µg/ml to 0.03 µg/ml.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Aspergillus</subject><subject>Aspergillus - classification</subject><subject>Aspergillus - metabolism</subject><subject>Bacteriology</subject><subject>Benzoquinones - chemistry</subject><subject>Benzoquinones - isolation & purification</subject><subject>Benzoquinones - metabolism</subject><subject>Benzoquinones - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Chemical Fractionation</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Synergism</subject><subject>Fermentation</subject><subject>Imipenem - pharmacology</subject><subject>Life Sciences</subject><subject>Liquid chromatography</subject><subject>Medicinal Chemistry</subject><subject>Methicillin Resistance</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Structure</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Silica</subject><subject>Solvent extraction</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUFv1DAQhS1ERbeFCz8AWULiAlnGseM4x1VFy4q2VCqcLa8z2fUqiVPbqbQ_gv9cr1okxGkO75unmfcIec9gyYCrr3uzLAGqZVO9IgumFCuYkM1rsgAoWaFUCafkLMY9AK95rd6QUyaFlFDyBflzn3CYdn7E-IXe-kfs6Z1POCZnkg-R-o6uBzfhiANd2eQeXTpQszVujIneYNo56_rejUXA6GIyY6L3yUy7Q--tt3aO1MwB52x-F3w7W2zp5kBXccKwzYtZj9OSXv5YFyXj8i056Uwf8d3LPCe_L7_9uvheXP-8Wl-srouJg0iFVbxqmq6Txqq229TQNFVbCxSWSSlAKVsbjp2SbanE8WWUnZG1hI6DNIrxc_Lp2XcK_mHGmPTgosW-NyP6OeoSSsEaEBn8-B-493MY822a1arO0bKqytSHF2reDNjqKbjBhIP-G3MGPj8DMUvjFsM_NqCPJeq90ccSdVPxJ6MXjQc</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Koyama, Nobuhiro</creator><creator>Nagahiro, Tomoko</creator><creator>Yamaguchi, Yuichi</creator><creator>Masuma, Rokuro</creator><creator>Tomoda, Hiroshi</creator><creator>Ōmura, Satoshi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20051101</creationdate><title>Stemphones, Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Aspergillus sp. 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Aspergillus
was found to produce potentiators of imipenem activity against methicillin-resistant
Staphylococcus aureus
(MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. These compounds have a common tetracyclic quinone skeleton. Stemphone C potentiated imipenem activity against the MRSA 512 fold by decreasing MIC value of imipenem from 16 µg/ml to 0.03 µg/ml.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16466023</pmid><doi>10.1038/ja.2005.95</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of antibiotics, 2005-11, Vol.58 (11), p.695-703 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents - pharmacology Aspergillus Aspergillus - classification Aspergillus - metabolism Bacteriology Benzoquinones - chemistry Benzoquinones - isolation & purification Benzoquinones - metabolism Benzoquinones - pharmacology Biomedical and Life Sciences Bioorganic Chemistry Chemical Fractionation Chromatography Chromatography, High Pressure Liquid Drug Synergism Fermentation Imipenem - pharmacology Life Sciences Liquid chromatography Medicinal Chemistry Methicillin Resistance Microbial Sensitivity Tests Microbiology Molecular Structure Organic Chemistry original-article Silica Solvent extraction Staphylococcus aureus Staphylococcus aureus - drug effects |
| title | Stemphones, Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Aspergillus sp. FKI-2136 |
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