Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response

Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously the in vitro efficacy of the Herpes Simplex Virus Thymidine kinase (HSV-tk)/ganciclovir (GCV) system to mediate cytotoxicity in oral squamous cancer cells, using transferrin (Tf)-lipoplexes, prepared...

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Veröffentlicht in:	Cancer gene therapy 2009-01, Vol.16 (1), p.91-101
Hauptverfasser:	Neves, S, Faneca, H, Bertin, S, Konopka, K, Düzgüneş, N, Pierrefite-Carle, V, Simões, S, Pedroso de Lima, M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites - pharmacology Antiviral Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics Apoptosis - immunology Biomedical and Life Sciences Biomedicine Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - therapy Care and treatment Cholesterol - chemistry Cholesterol - pharmacology Cytokines - immunology Diagnosis Fatty Acids, Monounsaturated - chemistry Fatty Acids, Monounsaturated - pharmacology Female Flucytosine - pharmacology Ganciclovir - pharmacology Gene Expression Gene Therapy Gene Transfer Techniques Genes, Transgenic, Suicide - genetics Genes, Transgenic, Suicide - immunology Genetic Therapy Health aspects Herpes simplex virus Liposomes - chemistry Liposomes - pharmacokinetics Lymphocytes - immunology Mice Mouth Neoplasms - enzymology Mouth Neoplasms - genetics Mouth Neoplasms - immunology Mouth Neoplasms - therapy original-article Physiological aspects Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Risk factors Simplexvirus - enzymology Simplexvirus - genetics Simplexvirus - immunology Squamous cell carcinoma Thymidine Kinase - genetics Thymidine Kinase - immunology Transferrin Viral Proteins - genetics
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