Lysosomal Trafficking and Cysteine Protease Metabolism Confer Target-specific Cytotoxicity by Peptide-linked Anti-CD30-Auristatin Conjugates

The chimeric anti-CD30 monoclonal antibody cAC10, linked to the antimitotic agents monomethyl auristatin E (MMAE) or F (MMAF), produces potent and highly CD30-selective anti-tumor activity in vitro and in vivo. These drugs are appended via a valine-citrulline (vc) dipeptide linkage designed for high...

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Veröffentlicht in:	The Journal of biological chemistry 2006-04, Vol.281 (15), p.10540-10547
Hauptverfasser:	Sutherland, May S. Kung, Sanderson, Russell J., Gordon, Kristine A., Andreyka, Jamie, Cerveny, Charles G., Yu, Changpu, Lewis, Timothy S., Meyer, Damon L., Zabinski, Roger F., Doronina, Svetlana O., Senter, Peter D., Law, Che-Leung, Wahl, Alan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antigens, CD20 - chemistry Antineoplastic Agents - pharmacology beta-Galactosidase - metabolism Blotting, Western Cathepsin B - chemistry Cell Line Cysteine Endopeptidases - chemistry Cysteine Proteinase Inhibitors - pharmacology Dose-Response Relationship, Drug Endocytosis Endopeptidases - chemistry Flow Cytometry Humans Inhibitory Concentration 50 Ki-1 Antigen - chemistry Lysosomes - metabolism Microscopy, Fluorescence Models, Chemical Oligopeptides - chemistry Peptide Hydrolases - chemistry Peptides - chemistry Protein Binding Subcellular Fractions - metabolism Temperature Time Factors
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