Effect of Ca2+ on the redox potential of heme a in cytochrome c oxidase

Subunit I of cytochrome c oxidase (CcO) from mitochondria and many bacteria contains a cation binding site (CBS) located at the outer positively charged aqueous phase not far from heme a. Binding of Ca2+ with the CBS in bovine CcO inhibits activity of the enzyme 2–3 -fold [Vygodina, T., Kirichenko,...

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Veröffentlicht in:	Biochimie 2018-06, Vol.149, p.71-78
Hauptverfasser:	Vygodina, Tatiana V., Kaminskaya, Olga P., Konstantinov, Alexander A., Ptushenko, Vasily V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium ions Cation binding site (CBS) Cytochrome c oxidase Heme a Potentiometric titrations
Online-Zugang:	Volltext
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