Acute Encephalitis Syndrome in Eastern Uttar Pradesh, India: Changing Etiological Understanding
Seasonal outbreaks of acute encephalitis syndrome (AES) with high case fatality have been occurring in Gorakhpur division in Eastern Uttar Pradesh, India, for more than three decades. Japanese encephalitis virus (JEV) accounted for
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Veröffentlicht in: | Journal of medical entomology 2018-05, Vol.55 (3), p.523-526 |
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creator | Murhekar, Manoj Thangaraj, Jeromie Wesley Vivian Mittal, Mahima Gupta, Nivedita |
description | Seasonal outbreaks of acute encephalitis syndrome (AES) with high case fatality have been occurring in Gorakhpur division in Eastern Uttar Pradesh, India, for more than three decades. Japanese encephalitis virus (JEV) accounted for |
doi_str_mv | 10.1093/jme/tjy042 |
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Japanese encephalitis virus (JEV) accounted for <10% of AES cases, while the etiology of the remaining cases remained largely unknown. Investigations conducted during the 2014 and 2015 outbreaks indicated Orientia tsutsugamushi (Haruo Hayashi 1920) (Norio Ogata 1929) Tamura et al. 1995 (Rickettsiales: Rickettsiaceae) as the etiology in about 60% of AES cases. Hospital-based surveillance studies indicated that about one-fifth of the patients with acute febrile illness were due to scrub typhus. Further studies are required to identify the etiology of about a third of AES cases that test negative for scrub typhus, JEV, or dengue.</description><identifier>ISSN: 0022-2585</identifier><identifier>EISSN: 1938-2928</identifier><identifier>DOI: 10.1093/jme/tjy042</identifier><identifier>PMID: 29635529</identifier><language>eng</language><publisher>England: Entomological Society of America</publisher><subject>Acute Febrile Encephalopathy - epidemiology ; Acute Febrile Encephalopathy - microbiology ; Adolescent ; Child ; Child, Preschool ; Dengue fever ; Disease Outbreaks ; Encephalitis ; Etiology ; FORUM ; Gorakhpur ; Humans ; India ; India - epidemiology ; Infant ; Infant, Newborn ; Japanese encephalitis ; Orientia tsutsugamushi ; Orientia tsutsugamushi - isolation & purification ; Outbreaks ; Scrub typhus ; Scrub Typhus - epidemiology ; Scrub Typhus - microbiology ; Typhus ; Vector-borne diseases ; Viral diseases ; Viruses</subject><ispartof>Journal of medical entomology, 2018-05, Vol.55 (3), p.523-526</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. journals.permissions@oup.com</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b348t-374b05331861925155dd148a526c4c18bb2c803f67d43ddc0c7144d5e6468dd3</citedby><cites>FETCH-LOGICAL-b348t-374b05331861925155dd148a526c4c18bb2c803f67d43ddc0c7144d5e6468dd3</cites><orcidid>0000-0002-1720-7628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29635529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murhekar, Manoj</creatorcontrib><creatorcontrib>Thangaraj, Jeromie Wesley Vivian</creatorcontrib><creatorcontrib>Mittal, Mahima</creatorcontrib><creatorcontrib>Gupta, Nivedita</creatorcontrib><title>Acute Encephalitis Syndrome in Eastern Uttar Pradesh, India: Changing Etiological Understanding</title><title>Journal of medical entomology</title><addtitle>J Med Entomol</addtitle><description>Seasonal outbreaks of acute encephalitis syndrome (AES) with high case fatality have been occurring in Gorakhpur division in Eastern Uttar Pradesh, India, for more than three decades. Japanese encephalitis virus (JEV) accounted for <10% of AES cases, while the etiology of the remaining cases remained largely unknown. Investigations conducted during the 2014 and 2015 outbreaks indicated Orientia tsutsugamushi (Haruo Hayashi 1920) (Norio Ogata 1929) Tamura et al. 1995 (Rickettsiales: Rickettsiaceae) as the etiology in about 60% of AES cases. Hospital-based surveillance studies indicated that about one-fifth of the patients with acute febrile illness were due to scrub typhus. Further studies are required to identify the etiology of about a third of AES cases that test negative for scrub typhus, JEV, or dengue.</description><subject>Acute Febrile Encephalopathy - epidemiology</subject><subject>Acute Febrile Encephalopathy - microbiology</subject><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dengue fever</subject><subject>Disease Outbreaks</subject><subject>Encephalitis</subject><subject>Etiology</subject><subject>FORUM</subject><subject>Gorakhpur</subject><subject>Humans</subject><subject>India</subject><subject>India - epidemiology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Japanese encephalitis</subject><subject>Orientia tsutsugamushi</subject><subject>Orientia tsutsugamushi - isolation & purification</subject><subject>Outbreaks</subject><subject>Scrub typhus</subject><subject>Scrub Typhus - epidemiology</subject><subject>Scrub Typhus - microbiology</subject><subject>Typhus</subject><subject>Vector-borne diseases</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>0022-2585</issn><issn>1938-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEtLAzEURoMotj42_gAJuBFxbJ7TjDsp9QGCgu06ZJK0TZlJapJZ9N87Uh_gwtXdnHv4OACcYXSDUUVH69aO8nqLGNkDQ1xRUZCKiH0wRIiQgnDBB-AopTVCSGBWHYIBqUrKOamGQN7pLls49dpuVqpx2SX4tvUmhtZC5-FUpWyjh_OcVYSvURmbVtfwyRunbuFkpfzS-SWcZheasHRaNXDujY0pqx7xyxNwsFBNsqdf9xjM7qezyWPx_PLwNLl7LmrKRC7omNWIU4pFiSvCMefGYCYUJ6VmGou6JloguijHhlFjNNJjzJjhtmSlMIYeg8uddhPDe2dTlq1L2jaN8jZ0SRJEGMJl_9OjF3_Qdeii78dJQktaCUrGoqeudpSOIaVoF3ITXaviVmIkP6vLvrrcVe_h8y9lV7fW_KDfmX_n1S4Eb_9zfQDTkYqq</recordid><startdate>20180504</startdate><enddate>20180504</enddate><creator>Murhekar, Manoj</creator><creator>Thangaraj, Jeromie Wesley Vivian</creator><creator>Mittal, Mahima</creator><creator>Gupta, Nivedita</creator><general>Entomological Society of America</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1720-7628</orcidid></search><sort><creationdate>20180504</creationdate><title>Acute Encephalitis Syndrome in Eastern Uttar Pradesh, India: Changing Etiological Understanding</title><author>Murhekar, Manoj ; 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Japanese encephalitis virus (JEV) accounted for <10% of AES cases, while the etiology of the remaining cases remained largely unknown. Investigations conducted during the 2014 and 2015 outbreaks indicated Orientia tsutsugamushi (Haruo Hayashi 1920) (Norio Ogata 1929) Tamura et al. 1995 (Rickettsiales: Rickettsiaceae) as the etiology in about 60% of AES cases. Hospital-based surveillance studies indicated that about one-fifth of the patients with acute febrile illness were due to scrub typhus. Further studies are required to identify the etiology of about a third of AES cases that test negative for scrub typhus, JEV, or dengue.</abstract><cop>England</cop><pub>Entomological Society of America</pub><pmid>29635529</pmid><doi>10.1093/jme/tjy042</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1720-7628</orcidid></addata></record> |
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subjects | Acute Febrile Encephalopathy - epidemiology Acute Febrile Encephalopathy - microbiology Adolescent Child Child, Preschool Dengue fever Disease Outbreaks Encephalitis Etiology FORUM Gorakhpur Humans India India - epidemiology Infant Infant, Newborn Japanese encephalitis Orientia tsutsugamushi Orientia tsutsugamushi - isolation & purification Outbreaks Scrub typhus Scrub Typhus - epidemiology Scrub Typhus - microbiology Typhus Vector-borne diseases Viral diseases Viruses |
title | Acute Encephalitis Syndrome in Eastern Uttar Pradesh, India: Changing Etiological Understanding |
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