The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

The stimulated nuclear translocation of signaling proteins, such as MAPKs, is a necessity for the initiation and regulation of their physiological functions. Previously, we determined that nuclear translocation of the MAPKs p38 and JNK involves binding to heterodimers comprising importin 3 and eithe...

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Veröffentlicht in:	Science signaling 2018-04, Vol.11 (525)
Hauptverfasser:	Maik-Rachline, Galia, Zehorai, Elder, Hanoch, Tamar, Blenis, John, Seger, Rony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animal tissues Binding Breast cancer Cancer Cell culture Cell proliferation Colitis Colon Colon cancer Colorectal cancer Gastrointestinal tract Inflammation Inflammatory bowel disease Intestine Irritable bowel syndrome JNK protein Kinases Macrophages Mice Nuclear transport Peptides Phosphorylation Proteins Side effects Signaling Substrates Translocation Tumor cell lines Tumors Xenografts Xenotransplantation
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