Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition

Programmed cell death-1 ligand-1 (PD-L1), essential for immune evasion, is a potential candidate for pathogenesis and therapeutic target of human papillomavirus (HPV)–positive tonsillar squamous cell carcinomas (TSCCs). MET/hepatocyte growth factor signaling and transcription factors involved in epi...

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Veröffentlicht in:	Human pathology 2018-10, Vol.80, p.28-39
Hauptverfasser:	Kwon, Mi Jung, Rho, Young-Soo, Nam, Eun Sook, Cho, Seong Jin, Park, Hye-Rim, Min, Soo Kee, Seo, Jinwon, Choe, Ji-Young, Kim, Eun Soo, Park, Bumjung, Hong, Mineui, Min, Kyueng-Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alcohol Antigens Apoptosis B7-H1 Antigen - metabolism Biomarkers, Tumor - analysis Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell death Cell Death - physiology Epithelial-Mesenchymal Transition - genetics Epithelial-to-mesenchymal transition Female Human papillomavirus Humans Kinases Ligands Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical prognosis Medical records Middle Aged Multivariate analysis Papillomaviridae - pathogenicity Patients Programmed cell death-1 ligand-1 Proteins Radiation therapy Squamous cell carcinoma Studies Tonsil Tonsillar Neoplasms - genetics Tonsillar Neoplasms - virology Transcription factors
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