Enhancement of the Antisense Effect of Polysaccharide–Polynucleotide Complexes by Preventing the Antisense Oligonucleotide from Binding to Proteins in the Culture Medium

Schizophyllan is a β-(1→3)-D-glucan existing as a triple helix in water and as a single chain in dimethyl sulfoxide (DMSO), respectively. As we already reported, when a homo-phosphodiester-polynucleotide is added to the schizophyllan/DMSO solution and, subsequently, DMSO is exchanged for water, the...

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Veröffentlicht in:	Bulletin of the Chemical Society of Japan 2004-06, Vol.77 (6), p.1101-1110
Hauptverfasser:	Mizu, Masami, Koumoto, Kazuya, Anada, Takahisa, Karinaga, Ryouji, Kimura, Taro, Nagasaki, Takeshi, Shinkai, Seiji, Sakurai, Kazuo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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