Diagnostic and Therapeutic Applications of Epigenetics
Epigenetic abnormalities, such as aberrant methylation of CpG islands, are inherited over cell divisions, and play important roles in carcinogenesis. Aberrant methylation of CpG islands specific to tumor cells can be used as a marker to detect cancer cells or cancer-derived DNA, taking advantage of...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2005-06, Vol.35 (6), p.293-301 |
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| container_title | Japanese journal of clinical oncology |
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| creator | Miyamoto, Kazuaki Ushijima, Toshikazu |
| description | Epigenetic abnormalities, such as aberrant methylation of CpG islands, are inherited over cell divisions, and play important roles in carcinogenesis. Aberrant methylation of CpG islands specific to tumor cells can be used as a marker to detect cancer cells or cancer-derived DNA, taking advantage of the high sensitivity of methods to detect aberrant methylation. Methylations of specific genes or methylation patterns of groups of genes were found to be associated with responses to chemotherapeutics and prognosis. Methylation in non-cancerous tissues is now attracting attention as a tumor risk marker, and is emerging as a target for cancer prevention. Epigenetic alterations are potentially reversible. The use of DNA demethylating agents has turned out to be effective for hematological malignancies, and is being tested in solid tumors. Histone deacetylase inhibitors and methods for gene-specific epigenetic modification are being developed. Application of epigenetics to cancer diagnostics and therapeutics, and possibly to cancer prevention, is coming into clinics. |
| doi_str_mv | 10.1093/jjco/hyi088 |
| format | Article |
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Aberrant methylation of CpG islands specific to tumor cells can be used as a marker to detect cancer cells or cancer-derived DNA, taking advantage of the high sensitivity of methods to detect aberrant methylation. Methylations of specific genes or methylation patterns of groups of genes were found to be associated with responses to chemotherapeutics and prognosis. Methylation in non-cancerous tissues is now attracting attention as a tumor risk marker, and is emerging as a target for cancer prevention. Epigenetic alterations are potentially reversible. The use of DNA demethylating agents has turned out to be effective for hematological malignancies, and is being tested in solid tumors. Histone deacetylase inhibitors and methods for gene-specific epigenetic modification are being developed. Application of epigenetics to cancer diagnostics and therapeutics, and possibly to cancer prevention, is coming into clinics.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - genetics</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>cancer therapy</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>CpG island</subject><subject>CpG Islands - genetics</subject><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Genes, p16</subject><subject>Glutathione S-Transferase pi</subject><subject>Glutathione Transferase - genetics</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Histone Deacetylases - metabolism</subject><subject>Humans</subject><subject>Isoenzymes - genetics</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - prevention & control</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - genetics</subject><subject>tumor marker</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0E1LxDAQBuAgiq4fJ--yePAi1ZmmadKj3wqCCiriJaTJRLPutrVpQf-9XXZR8DQM8_AyvIztIhwhFPx4MrH18ft3AKVW2AizXCQ8T3GVjYDnKkkV4gbbjHECAEJlcp1toCg4AFcjlp8H81bVsQt2bCo3fnyn1jTUz_eTppkGa7pQV3Fc-_FFE96oouEUt9maN9NIO8u5xZ4uLx7PrpPbu6ubs5PbxAqELlEOc-FUKaSzpARlyoOXIIFjWaa2KNF4SVhaMk55J9KCKHMOvM8Kkq7gW-xgkdu09WdPsdOzEC1Np6aiuo86hZQrzHGA-__gpO7bavhNpygRuYR8QIcLZNs6xpa8btowM-23RtDzLvW8S73octB7y8i-nJH7s8vyBpAsQIgdff3eTfuhc8ml0Ncvr_rhAeA5vbrXp_wHpF9_8Q</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Miyamoto, Kazuaki</creator><creator>Ushijima, Toshikazu</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>200506</creationdate><title>Diagnostic and Therapeutic Applications of Epigenetics</title><author>Miyamoto, Kazuaki ; Ushijima, Toshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-8d165d8b57dce85e48f0f707031bb2c9b1af7e1bcead8fd529ee4dd0ff49e7d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - genetics</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>cancer therapy</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>CpG island</topic><topic>CpG Islands - genetics</topic><topic>DNA Methylation</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Genes, p16</topic><topic>Glutathione S-Transferase pi</topic><topic>Glutathione Transferase - genetics</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Histone Deacetylases - metabolism</topic><topic>Humans</topic><topic>Isoenzymes - genetics</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - prevention & control</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - genetics</topic><topic>tumor marker</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyamoto, Kazuaki</creatorcontrib><creatorcontrib>Ushijima, Toshikazu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyamoto, Kazuaki</au><au>Ushijima, Toshikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic and Therapeutic Applications of Epigenetics</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>JJCO</addtitle><date>2005-06</date><risdate>2005</risdate><volume>35</volume><issue>6</issue><spage>293</spage><epage>301</epage><pages>293-301</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>Epigenetic abnormalities, such as aberrant methylation of CpG islands, are inherited over cell divisions, and play important roles in carcinogenesis. Aberrant methylation of CpG islands specific to tumor cells can be used as a marker to detect cancer cells or cancer-derived DNA, taking advantage of the high sensitivity of methods to detect aberrant methylation. Methylations of specific genes or methylation patterns of groups of genes were found to be associated with responses to chemotherapeutics and prognosis. Methylation in non-cancerous tissues is now attracting attention as a tumor risk marker, and is emerging as a target for cancer prevention. Epigenetic alterations are potentially reversible. The use of DNA demethylating agents has turned out to be effective for hematological malignancies, and is being tested in solid tumors. Histone deacetylase inhibitors and methods for gene-specific epigenetic modification are being developed. Application of epigenetics to cancer diagnostics and therapeutics, and possibly to cancer prevention, is coming into clinics.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>15930038</pmid><doi>10.1093/jjco/hyi088</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0368-2811 |
| ispartof | Japanese journal of clinical oncology, 2005-06, Vol.35 (6), p.293-301 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biomarkers, Tumor - genetics Breast Neoplasms - diagnosis Breast Neoplasms - genetics Bronchoalveolar Lavage Fluid - chemistry cancer therapy Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics CpG island CpG Islands - genetics DNA Methylation Epigenesis, Genetic Epigenetics Female Genes, p16 Glutathione S-Transferase pi Glutathione Transferase - genetics Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - genetics Histone Deacetylases - metabolism Humans Isoenzymes - genetics Lung Neoplasms - diagnosis Lung Neoplasms - genetics Male Neoplasms - diagnosis Neoplasms - genetics Neoplasms - prevention & control Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics tumor marker |
| title | Diagnostic and Therapeutic Applications of Epigenetics |
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