Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl super(-) transport and overexpression can generate basolateral CFTR

Gene transfer of CFTR cDNA to airway epithelia is a promising approach to treat cystic fibrosis (CF). Most gene transfer vectors use strong viral promoters even though the endogenous CFTR promoter is very weak. To learn whether expressing CFTR at a low level in a fraction of cells would correct Cl s...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2005-12, Vol.289 (6), p.L1123-L1130
Hauptverfasser:	Farmen, Sara L, Karp, Philip H, Ng, Philip, Palmer, Donna J, Koehler, David R, Hu, Jim, Beaudet, Arthur L, Zabner, Joseph, Welsh, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytomegalovirus
Online-Zugang:	Volltext
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