Use of drug intoxicated donors for lung transplant: Impact on survival outcomes

Use of drug intoxicated donors for lung transplant: Impact on survival outcomes

Introduction The number of increasing deaths due to the opioid epidemic has led to a potential greater supply of organ donors. There is hesitancy to use drug intoxicated donors, and we evaluated their impact on post‐transplant survival. Background Patients ≥18 years of age undergoing lung transplant...

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Veröffentlicht in:Clinical transplantation 2018-05, Vol.32 (5), p.e13252-n/a
Hauptverfasser: Whited, William M., Ising, Mickey S., Trivedi, Jaimin R., Fox, Matthew P., Berkel, Victor
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donor lungs
drug intoxication
lung transplantation
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container_end_page n/a
container_issue 5
container_start_page e13252
container_title Clinical transplantation
container_volume 32
creator Whited, William M.
Ising, Mickey S.
Trivedi, Jaimin R.
Fox, Matthew P.
Berkel, Victor
description Introduction The number of increasing deaths due to the opioid epidemic has led to a potential greater supply of organ donors. There is hesitancy to use drug intoxicated donors, and we evaluated their impact on post‐transplant survival. Background Patients ≥18 years of age undergoing lung transplantation and donors from whom at least one organ was donated between January 2005 and March 2015 were selected from the United Network of Organ Sharing database. Baseline characteristics and post‐transplant survival were compared between drug intoxicated and all other donors. Results The utilization of drug intoxicated donors increased from 1.86% in 2005 to 6.23% in 2014. The 2 study groups had similar characteristics including age, gender, and Lung Allocation Score. As compared to all other donors, drug intoxicated donors were younger (29.1 ± 9.4 vs 34.6 ± 13.4 years, P 
doi_str_mv 10.1111/ctr.13252
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There is hesitancy to use drug intoxicated donors, and we evaluated their impact on post‐transplant survival. Background Patients ≥18 years of age undergoing lung transplantation and donors from whom at least one organ was donated between January 2005 and March 2015 were selected from the United Network of Organ Sharing database. Baseline characteristics and post‐transplant survival were compared between drug intoxicated and all other donors. Results The utilization of drug intoxicated donors increased from 1.86% in 2005 to 6.23% in 2014. The 2 study groups had similar characteristics including age, gender, and Lung Allocation Score. As compared to all other donors, drug intoxicated donors were younger (29.1 ± 9.4 vs 34.6 ± 13.4 years, P &lt; .0001), less likely to be male (52% vs 61%, P &lt; .0001), and had a greater smoking history (14% vs 11%, P .04). There was no difference in post–lung transplant survival at 1, 3, and 5 years between drug intoxicated donors (85%, 64%, and 47%) and non‐drug intoxicated donors (83%, 65%, and 51%). Conclusion Transplantation utilizing drug intoxicated donor lungs has significantly increased over the past decade without significantly impacting post‐transplant survival.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/ctr.13252</identifier><identifier>PMID: 29633364</identifier><language>eng</language><publisher>Denmark</publisher><subject>donor lungs ; drug intoxication ; lung transplantation</subject><ispartof>Clinical transplantation, 2018-05, Vol.32 (5), p.e13252-n/a</ispartof><rights>2018 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2018 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3252-77535285c18fe19aec900a1b42e4e4febf024a097420fde032132b005ea5280c3</citedby><cites>FETCH-LOGICAL-c3252-77535285c18fe19aec900a1b42e4e4febf024a097420fde032132b005ea5280c3</cites><orcidid>0000-0002-8951-167X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fctr.13252$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fctr.13252$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29633364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whited, William M.</creatorcontrib><creatorcontrib>Ising, Mickey S.</creatorcontrib><creatorcontrib>Trivedi, Jaimin R.</creatorcontrib><creatorcontrib>Fox, Matthew P.</creatorcontrib><creatorcontrib>Berkel, Victor</creatorcontrib><title>Use of drug intoxicated donors for lung transplant: Impact on survival outcomes</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>Introduction The number of increasing deaths due to the opioid epidemic has led to a potential greater supply of organ donors. There is hesitancy to use drug intoxicated donors, and we evaluated their impact on post‐transplant survival. Background Patients ≥18 years of age undergoing lung transplantation and donors from whom at least one organ was donated between January 2005 and March 2015 were selected from the United Network of Organ Sharing database. Baseline characteristics and post‐transplant survival were compared between drug intoxicated and all other donors. Results The utilization of drug intoxicated donors increased from 1.86% in 2005 to 6.23% in 2014. The 2 study groups had similar characteristics including age, gender, and Lung Allocation Score. As compared to all other donors, drug intoxicated donors were younger (29.1 ± 9.4 vs 34.6 ± 13.4 years, P &lt; .0001), less likely to be male (52% vs 61%, P &lt; .0001), and had a greater smoking history (14% vs 11%, P .04). There was no difference in post–lung transplant survival at 1, 3, and 5 years between drug intoxicated donors (85%, 64%, and 47%) and non‐drug intoxicated donors (83%, 65%, and 51%). Conclusion Transplantation utilizing drug intoxicated donor lungs has significantly increased over the past decade without significantly impacting post‐transplant survival.</description><subject>donor lungs</subject><subject>drug intoxication</subject><subject>lung transplantation</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EoqWw4AeQl7AI9SOPhh2qeFSqVAm1a8txxlVQEgfbKfTvcUlhx2xmNDpzdecidE3JPQ01Vd7eU84SdoLGlOd5RAhlp2hMcsLCnPIRunDuPWxTmibnaMTylHOexmO02jjARuPS9ltctd58VUp6KHFpWmMd1sbium-32FvZuq6WrX_Ai6aTymPTYtfbXbWTNTa9V6YBd4nOtKwdXB37BG2en9bz12i5elnMH5eROviMsizhCZslis400FyCygmRtIgZxBBrKDRhsSR5FjOiSyCchf8KQhKQ4YwoPkG3g25nzUcPzoumcgrqYBBM7wQjjGcs3NOA3g2ossY5C1p0tmqk3QtKxCE_EfITP_kF9uYo2xcNlH_kb2ABmA7AZ1XD_n8lMV-_DZLfnlx5Qg</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Whited, William M.</creator><creator>Ising, Mickey S.</creator><creator>Trivedi, Jaimin R.</creator><creator>Fox, Matthew P.</creator><creator>Berkel, Victor</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8951-167X</orcidid></search><sort><creationdate>201805</creationdate><title>Use of drug intoxicated donors for lung transplant: Impact on survival outcomes</title><author>Whited, William M. ; Ising, Mickey S. ; Trivedi, Jaimin R. ; Fox, Matthew P. ; Berkel, Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3252-77535285c18fe19aec900a1b42e4e4febf024a097420fde032132b005ea5280c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>donor lungs</topic><topic>drug intoxication</topic><topic>lung transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whited, William M.</creatorcontrib><creatorcontrib>Ising, Mickey S.</creatorcontrib><creatorcontrib>Trivedi, Jaimin R.</creatorcontrib><creatorcontrib>Fox, Matthew P.</creatorcontrib><creatorcontrib>Berkel, Victor</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whited, William M.</au><au>Ising, Mickey S.</au><au>Trivedi, Jaimin R.</au><au>Fox, Matthew P.</au><au>Berkel, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of drug intoxicated donors for lung transplant: Impact on survival outcomes</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2018-05</date><risdate>2018</risdate><volume>32</volume><issue>5</issue><spage>e13252</spage><epage>n/a</epage><pages>e13252-n/a</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>Introduction The number of increasing deaths due to the opioid epidemic has led to a potential greater supply of organ donors. There is hesitancy to use drug intoxicated donors, and we evaluated their impact on post‐transplant survival. Background Patients ≥18 years of age undergoing lung transplantation and donors from whom at least one organ was donated between January 2005 and March 2015 were selected from the United Network of Organ Sharing database. Baseline characteristics and post‐transplant survival were compared between drug intoxicated and all other donors. Results The utilization of drug intoxicated donors increased from 1.86% in 2005 to 6.23% in 2014. The 2 study groups had similar characteristics including age, gender, and Lung Allocation Score. As compared to all other donors, drug intoxicated donors were younger (29.1 ± 9.4 vs 34.6 ± 13.4 years, P &lt; .0001), less likely to be male (52% vs 61%, P &lt; .0001), and had a greater smoking history (14% vs 11%, P .04). There was no difference in post–lung transplant survival at 1, 3, and 5 years between drug intoxicated donors (85%, 64%, and 47%) and non‐drug intoxicated donors (83%, 65%, and 51%). Conclusion Transplantation utilizing drug intoxicated donor lungs has significantly increased over the past decade without significantly impacting post‐transplant survival.</abstract><cop>Denmark</cop><pmid>29633364</pmid><doi>10.1111/ctr.13252</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8951-167X</orcidid></addata></record>
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subjects donor lungs
drug intoxication
lung transplantation
title Use of drug intoxicated donors for lung transplant: Impact on survival outcomes
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