Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro

DEP domain containing 1 (DEPDC1) and M-phase phosphoprotein 1 (MPHOSPH1) are human cancer testis antigens that are frequently overexpressed in urinary bladder cancer. In a phase I/II clinical trial, a DEPDC1- and MPHOSPH1-derived short peptide vaccine demonstrated promising efficacy in preventing bl...

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Veröffentlicht in:	Oncoimmunology 2018-04, Vol.7 (4), p.e1415687-e1415687
Hauptverfasser:	Tsuruta, Miki, Ueda, Shohei, Yew, Poh Yin, Fukuda, Isao, Yoshimura, Sachiko, Kishi, Hiroyuki, Hamana, Hiroshi, Hirayama, Masatoshi, Yatsuda, Junji, Irie, Atsushi, Senju, Satoru, Yuba, Eiji, Kamba, Tomomi, Eto, Masatoshi, Nakayama, Hideki, Nishimura, Yasuharu
Format:	Artikel
Sprache:	eng
Schlagworte:	bladder cancer cancer immunotherapy cancer-testis antigen cross presentation DEP domain containing 1 helper T-cell epitope M-phase phosphoprotein 1 Original Research T-cell receptor tumor immunity
Online-Zugang:	Volltext
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