INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO

Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. In vi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Acta Poloniae pharmaceutica 2016-11, Vol.73 (6), p.1531-1538
Hauptverfasser:	Bilska-Wilkosz, Anna, Gorny, Magdalena, Dudek, Magdalena, Nowinski, Leszek, Bednarski, Marek, Iciek, Malgorzata, Kowalczyk-Pachel, Danuta, Sokolowska-Jezewicz, Maria, Filipek, Barbara, Wlodek, Lidia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase - metabolism Animals Liver - drug effects Liver - enzymology Male Nitroglycerin - pharmacology Rats Rats, Wistar Thioctic Acid - analogs & derivatives Thioctic Acid - metabolism Thioctic Acid - pharmacology Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!