INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO
Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. In vi...
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| Veröffentlicht in: | Acta Poloniae pharmaceutica 2016-11, Vol.73 (6), p.1531-1538 |
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| container_title | Acta Poloniae pharmaceutica |
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| creator | Bilska-Wilkosz, Anna Gorny, Magdalena Dudek, Magdalena Nowinski, Leszek Bednarski, Marek Iciek, Malgorzata Kowalczyk-Pachel, Danuta Sokolowska-Jezewicz, Maria Filipek, Barbara Wlodek, Lidia |
| description | Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. In vivo studies were performed to answer the question whether LA administered jointly with GTN for 8 days will affect the ALDH activity in the rat liver. The results indicated that in vito both LA and DHLA restored and protected ALDH activity against GTN-induced inactivation, while treatment of rats with LA and GTN in combination did not provide any protection against GTN-induced ALDH inhibition. In summary, the obtained results seem to confirm earlier reports indicating the differential effects of LA in vitio and in vivo. |
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IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Bilska-Wilkosz, Anna ; Gorny, Magdalena ; Dudek, Magdalena ; Nowinski, Leszek ; Bednarski, Marek ; Iciek, Malgorzata ; Kowalczyk-Pachel, Danuta ; Sokolowska-Jezewicz, Maria ; Filipek, Barbara ; Wlodek, Lidia</creator><creatorcontrib>Bilska-Wilkosz, Anna ; Gorny, Magdalena ; Dudek, Magdalena ; Nowinski, Leszek ; Bednarski, Marek ; Iciek, Malgorzata ; Kowalczyk-Pachel, Danuta ; Sokolowska-Jezewicz, Maria ; Filipek, Barbara ; Wlodek, Lidia</creatorcontrib><description>Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. In vivo studies were performed to answer the question whether LA administered jointly with GTN for 8 days will affect the ALDH activity in the rat liver. The results indicated that in vito both LA and DHLA restored and protected ALDH activity against GTN-induced inactivation, while treatment of rats with LA and GTN in combination did not provide any protection against GTN-induced ALDH inhibition. In summary, the obtained results seem to confirm earlier reports indicating the differential effects of LA in vitio and in vivo.</description><identifier>ISSN: 0001-6837</identifier><identifier>PMID: 29634107</identifier><language>eng</language><publisher>Poland</publisher><subject>Aldehyde Dehydrogenase - antagonists & inhibitors ; Aldehyde Dehydrogenase - metabolism ; Animals ; Liver - drug effects ; Liver - enzymology ; Male ; Nitroglycerin - pharmacology ; Rats ; Rats, Wistar ; Thioctic Acid - analogs & derivatives ; Thioctic Acid - metabolism ; Thioctic Acid - pharmacology ; Vasodilator Agents - pharmacology</subject><ispartof>Acta Poloniae pharmaceutica, 2016-11, Vol.73 (6), p.1531-1538</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29634107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bilska-Wilkosz, Anna</creatorcontrib><creatorcontrib>Gorny, Magdalena</creatorcontrib><creatorcontrib>Dudek, Magdalena</creatorcontrib><creatorcontrib>Nowinski, Leszek</creatorcontrib><creatorcontrib>Bednarski, Marek</creatorcontrib><creatorcontrib>Iciek, Malgorzata</creatorcontrib><creatorcontrib>Kowalczyk-Pachel, Danuta</creatorcontrib><creatorcontrib>Sokolowska-Jezewicz, Maria</creatorcontrib><creatorcontrib>Filipek, Barbara</creatorcontrib><creatorcontrib>Wlodek, Lidia</creatorcontrib><title>INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO</title><title>Acta Poloniae pharmaceutica</title><addtitle>Acta Pol Pharm</addtitle><description>Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. In vivo studies were performed to answer the question whether LA administered jointly with GTN for 8 days will affect the ALDH activity in the rat liver. The results indicated that in vito both LA and DHLA restored and protected ALDH activity against GTN-induced inactivation, while treatment of rats with LA and GTN in combination did not provide any protection against GTN-induced ALDH inhibition. In summary, the obtained results seem to confirm earlier reports indicating the differential effects of LA in vitio and in vivo.</description><subject>Aldehyde Dehydrogenase - antagonists & inhibitors</subject><subject>Aldehyde Dehydrogenase - metabolism</subject><subject>Animals</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Nitroglycerin - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thioctic Acid - analogs & derivatives</subject><subject>Thioctic Acid - metabolism</subject><subject>Thioctic Acid - pharmacology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0001-6837</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rwjAUhnuxMcXtL4xc7saRj7aplzFNNRATaTvBq9L0Axw6ndWL_c79ocXqYAxyOOc95_C8B3LnDSGEaBxGhA68p657dxIGPp0g9OAN8CQkPoJ06H1LzXguVyyXRgOTAKZiMV_HAvQpNTOhWSbAdA20zJ1Uay5SqYF7-VyAZSoyobkATMeATa-1wyi5NJIDxmXcj2LZ0_60X4FcLJXkvXMGEpPegGaqxOLCiGWSiFToXDIFhKt5nv1nuzNWl7t6k16szKN335bbrnm65ZH3loicz8fKzJyfGh8wQqdxVWPahi7aKIwq6wckwo2tSEkqaGkIa9Ri6tMa4cDaFjXEWouIRaEto6CtJmTkvVy5h-P-89x0p2K36apmuy0_mv25KzDEhGIaRKFbfb6tnu2uqYvDcbMrj1_F70eQH-ouc7s</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Bilska-Wilkosz, Anna</creator><creator>Gorny, Magdalena</creator><creator>Dudek, Magdalena</creator><creator>Nowinski, Leszek</creator><creator>Bednarski, Marek</creator><creator>Iciek, Malgorzata</creator><creator>Kowalczyk-Pachel, Danuta</creator><creator>Sokolowska-Jezewicz, Maria</creator><creator>Filipek, Barbara</creator><creator>Wlodek, Lidia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO</title><author>Bilska-Wilkosz, Anna ; Gorny, Magdalena ; Dudek, Magdalena ; Nowinski, Leszek ; Bednarski, Marek ; Iciek, Malgorzata ; Kowalczyk-Pachel, Danuta ; Sokolowska-Jezewicz, Maria ; Filipek, Barbara ; Wlodek, Lidia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-cd27f627ff868cb45382ebc3a3c0b760d1f2747d125bbf1e3bbb13b16ba85fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aldehyde Dehydrogenase - antagonists & inhibitors</topic><topic>Aldehyde Dehydrogenase - metabolism</topic><topic>Animals</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Nitroglycerin - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thioctic Acid - analogs & derivatives</topic><topic>Thioctic Acid - metabolism</topic><topic>Thioctic Acid - pharmacology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilska-Wilkosz, Anna</creatorcontrib><creatorcontrib>Gorny, Magdalena</creatorcontrib><creatorcontrib>Dudek, Magdalena</creatorcontrib><creatorcontrib>Nowinski, Leszek</creatorcontrib><creatorcontrib>Bednarski, Marek</creatorcontrib><creatorcontrib>Iciek, Malgorzata</creatorcontrib><creatorcontrib>Kowalczyk-Pachel, Danuta</creatorcontrib><creatorcontrib>Sokolowska-Jezewicz, Maria</creatorcontrib><creatorcontrib>Filipek, Barbara</creatorcontrib><creatorcontrib>Wlodek, Lidia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Poloniae pharmaceutica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilska-Wilkosz, Anna</au><au>Gorny, Magdalena</au><au>Dudek, Magdalena</au><au>Nowinski, Leszek</au><au>Bednarski, Marek</au><au>Iciek, Malgorzata</au><au>Kowalczyk-Pachel, Danuta</au><au>Sokolowska-Jezewicz, Maria</au><au>Filipek, Barbara</au><au>Wlodek, Lidia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO</atitle><jtitle>Acta Poloniae pharmaceutica</jtitle><addtitle>Acta Pol Pharm</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>73</volume><issue>6</issue><spage>1531</spage><epage>1538</epage><pages>1531-1538</pages><issn>0001-6837</issn><abstract>Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglycerin (GTN) in the presence and absence of LA and DHLA. In vivo studies were performed to answer the question whether LA administered jointly with GTN for 8 days will affect the ALDH activity in the rat liver. The results indicated that in vito both LA and DHLA restored and protected ALDH activity against GTN-induced inactivation, while treatment of rats with LA and GTN in combination did not provide any protection against GTN-induced ALDH inhibition. In summary, the obtained results seem to confirm earlier reports indicating the differential effects of LA in vitio and in vivo.</abstract><cop>Poland</cop><pmid>29634107</pmid><tpages>8</tpages></addata></record> |
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| subjects | Aldehyde Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase - metabolism Animals Liver - drug effects Liver - enzymology Male Nitroglycerin - pharmacology Rats Rats, Wistar Thioctic Acid - analogs & derivatives Thioctic Acid - metabolism Thioctic Acid - pharmacology Vasodilator Agents - pharmacology |
| title | INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO |
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