Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation
Permeability of tumor vasculature can be a major barrier to successful drug delivery, particularly for high molecular weight agents such as monoclonal antibodies and their diagnostic or therapeutic conjugates. In this study, changes in permeability of SCCVII tumor vessels after radiation treatment w...
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| Veröffentlicht in: | Clinical cancer research 2004-11, Vol.10 (22), p.7712-7720 |
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| creator | KOBAYASHI, Hisataka REIJNDERS, Koen BRECHBIEL, Martin W ENGLISH, Sean YORDANOV, Alexander T MILENIC, Diane E SOWERS, Anastasia L CITRIN, Deborah KRISHNA, Murali C WALDMANN, Thomas A MITCHELL, James B |
| description | Permeability of tumor vasculature can be a major barrier to successful drug delivery, particularly for high molecular weight
agents such as monoclonal antibodies and their diagnostic or therapeutic conjugates. In this study, changes in permeability
of SCCVII tumor vessels after radiation treatment were evaluated by dynamic magnetic resonance imaging as a function of time
after irradiation using a generation-8 polyamidoamine dendrimer (G8-Gd-D)-based magnetic resonance imaging contrast agent
shown previously to be confined to tumor blood vessels. Tumor irradiation consisted of either single doses (2–15 Gy) or various
daily fractionated doses (5 days). A single radiation dose of 15 Gy resulted in significant transient image enhancement of
the tumor tissue with a maximum occurring between 7 and 24 hours after radiation treatment. No observable enhancement was
recorded for fractionated radiation doses. Use of dynamic magnetic resonance imaging coupled with G8-Gd-D provides an exquisite
methodology capable of defining the timing of enhanced permeability of macromolecules in tumors after irradiation. Such information
might be applied to optimize the efficacy of subsequent or concurrent therapies including radiolabeled antibodies or other
anticancer agents in combination with external beam therapies. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-1175 |
| format | Article |
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agents such as monoclonal antibodies and their diagnostic or therapeutic conjugates. In this study, changes in permeability
of SCCVII tumor vessels after radiation treatment were evaluated by dynamic magnetic resonance imaging as a function of time
after irradiation using a generation-8 polyamidoamine dendrimer (G8-Gd-D)-based magnetic resonance imaging contrast agent
shown previously to be confined to tumor blood vessels. Tumor irradiation consisted of either single doses (2–15 Gy) or various
daily fractionated doses (5 days). A single radiation dose of 15 Gy resulted in significant transient image enhancement of
the tumor tissue with a maximum occurring between 7 and 24 hours after radiation treatment. No observable enhancement was
recorded for fractionated radiation doses. Use of dynamic magnetic resonance imaging coupled with G8-Gd-D provides an exquisite
methodology capable of defining the timing of enhanced permeability of macromolecules in tumors after irradiation. Such information
might be applied to optimize the efficacy of subsequent or concurrent therapies including radiolabeled antibodies or other
anticancer agents in combination with external beam therapies.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-1175</identifier><identifier>PMID: 15570005</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Amines - chemistry ; Amines - pharmacology ; Animals ; Antibodies, Monoclonal - chemistry ; Antineoplastic agents ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Contrast Media - pharmacology ; Female ; Image Processing, Computer-Assisted ; Macromolecular Substances - chemistry ; Magnetic Resonance Imaging ; Medical sciences ; Mice ; Mice, Inbred C3H ; Neoplasm Transplantation ; Neoplasms - blood supply ; Neoplasms, Radiation-Induced - pathology ; Neovascularization, Pathologic ; Nylons - chemistry ; Nylons - pharmacology ; Pharmacology. Drug treatments ; Time Factors</subject><ispartof>Clinical cancer research, 2004-11, Vol.10 (22), p.7712-7720</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-71a703975c5917fefba8bf65207f33af2d0b3cbf069d87cf3cdbd81aad633f9a3</citedby><cites>FETCH-LOGICAL-c513t-71a703975c5917fefba8bf65207f33af2d0b3cbf069d87cf3cdbd81aad633f9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3343,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16287263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15570005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOBAYASHI, Hisataka</creatorcontrib><creatorcontrib>REIJNDERS, Koen</creatorcontrib><creatorcontrib>BRECHBIEL, Martin W</creatorcontrib><creatorcontrib>ENGLISH, Sean</creatorcontrib><creatorcontrib>YORDANOV, Alexander T</creatorcontrib><creatorcontrib>MILENIC, Diane E</creatorcontrib><creatorcontrib>SOWERS, Anastasia L</creatorcontrib><creatorcontrib>CITRIN, Deborah</creatorcontrib><creatorcontrib>KRISHNA, Murali C</creatorcontrib><creatorcontrib>WALDMANN, Thomas A</creatorcontrib><creatorcontrib>MITCHELL, James B</creatorcontrib><title>Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Permeability of tumor vasculature can be a major barrier to successful drug delivery, particularly for high molecular weight
agents such as monoclonal antibodies and their diagnostic or therapeutic conjugates. In this study, changes in permeability
of SCCVII tumor vessels after radiation treatment were evaluated by dynamic magnetic resonance imaging as a function of time
after irradiation using a generation-8 polyamidoamine dendrimer (G8-Gd-D)-based magnetic resonance imaging contrast agent
shown previously to be confined to tumor blood vessels. Tumor irradiation consisted of either single doses (2–15 Gy) or various
daily fractionated doses (5 days). A single radiation dose of 15 Gy resulted in significant transient image enhancement of
the tumor tissue with a maximum occurring between 7 and 24 hours after radiation treatment. No observable enhancement was
recorded for fractionated radiation doses. Use of dynamic magnetic resonance imaging coupled with G8-Gd-D provides an exquisite
methodology capable of defining the timing of enhanced permeability of macromolecules in tumors after irradiation. Such information
might be applied to optimize the efficacy of subsequent or concurrent therapies including radiolabeled antibodies or other
anticancer agents in combination with external beam therapies.</description><subject>Amines - chemistry</subject><subject>Amines - pharmacology</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - chemistry</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Contrast Media - pharmacology</subject><subject>Female</subject><subject>Image Processing, Computer-Assisted</subject><subject>Macromolecular Substances - chemistry</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms - blood supply</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Neovascularization, Pathologic</subject><subject>Nylons - chemistry</subject><subject>Nylons - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi0EoqXwE0C-gMQhxR_rOHtchQKVWoGqwtWaOOOukZMstqNqD_3vON2tevJr6XlnRg8h7zk751w1XzjTTcVWUpy37U0JFedavSCnXCldSVGrlyU_MSfkTUp_GeMrzlavyckCMcbUKXnY7HbBW8h-GunkKNBrsHEapoB2DhBpO405Qsp0c4djpm6K9CtmtE-FTcgYH-tp-d7OQyH-YEoY6C-MA0Lng897ejn2s8Wednt6A71_rLwlrxyEhO-O7xn5_e3itv1RXf38ftluriqruMyV5qCZXGtl1Zprh66DpnO1Ekw7KcGJnnXSdo7V677R1knbd33DAfpaSrcGeUY-Hebu4vRvxpTN4JPFEGDEaU5GMCE1F3UB1QEsDlKK6Mwu-gHi3nBmFu9mcWoWp6Z4L8Es3kvvw3HB3A3YP7eOogvw8QhAshBchNH69MzVotFlf-E-H7itv9ve-4jGFhJjxIQQ7Xa5Qwijy7XyP80-m7Y</recordid><startdate>20041115</startdate><enddate>20041115</enddate><creator>KOBAYASHI, Hisataka</creator><creator>REIJNDERS, Koen</creator><creator>BRECHBIEL, Martin W</creator><creator>ENGLISH, Sean</creator><creator>YORDANOV, Alexander T</creator><creator>MILENIC, Diane E</creator><creator>SOWERS, Anastasia L</creator><creator>CITRIN, Deborah</creator><creator>KRISHNA, Murali C</creator><creator>WALDMANN, Thomas A</creator><creator>MITCHELL, James B</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20041115</creationdate><title>Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation</title><author>KOBAYASHI, Hisataka ; REIJNDERS, Koen ; BRECHBIEL, Martin W ; ENGLISH, Sean ; YORDANOV, Alexander T ; MILENIC, Diane E ; SOWERS, Anastasia L ; CITRIN, Deborah ; KRISHNA, Murali C ; WALDMANN, Thomas A ; MITCHELL, James B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-71a703975c5917fefba8bf65207f33af2d0b3cbf069d87cf3cdbd81aad633f9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amines - chemistry</topic><topic>Amines - pharmacology</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - chemistry</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Contrast Media - pharmacology</topic><topic>Female</topic><topic>Image Processing, Computer-Assisted</topic><topic>Macromolecular Substances - chemistry</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms - blood supply</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Neovascularization, Pathologic</topic><topic>Nylons - chemistry</topic><topic>Nylons - pharmacology</topic><topic>Pharmacology. 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agents such as monoclonal antibodies and their diagnostic or therapeutic conjugates. In this study, changes in permeability
of SCCVII tumor vessels after radiation treatment were evaluated by dynamic magnetic resonance imaging as a function of time
after irradiation using a generation-8 polyamidoamine dendrimer (G8-Gd-D)-based magnetic resonance imaging contrast agent
shown previously to be confined to tumor blood vessels. Tumor irradiation consisted of either single doses (2–15 Gy) or various
daily fractionated doses (5 days). A single radiation dose of 15 Gy resulted in significant transient image enhancement of
the tumor tissue with a maximum occurring between 7 and 24 hours after radiation treatment. No observable enhancement was
recorded for fractionated radiation doses. Use of dynamic magnetic resonance imaging coupled with G8-Gd-D provides an exquisite
methodology capable of defining the timing of enhanced permeability of macromolecules in tumors after irradiation. Such information
might be applied to optimize the efficacy of subsequent or concurrent therapies including radiolabeled antibodies or other
anticancer agents in combination with external beam therapies.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15570005</pmid><doi>10.1158/1078-0432.CCR-04-1175</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2004-11, Vol.10 (22), p.7712-7720 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20237126 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research; Alma/SFX Local Collection |
| subjects | Amines - chemistry Amines - pharmacology Animals Antibodies, Monoclonal - chemistry Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Contrast Media - pharmacology Female Image Processing, Computer-Assisted Macromolecular Substances - chemistry Magnetic Resonance Imaging Medical sciences Mice Mice, Inbred C3H Neoplasm Transplantation Neoplasms - blood supply Neoplasms, Radiation-Induced - pathology Neovascularization, Pathologic Nylons - chemistry Nylons - pharmacology Pharmacology. Drug treatments Time Factors |
| title | Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation |
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