Novel enzymatic route for kinetic resolution of (±)1,4-benzodioxan-2-carboxylic acid

Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterification reaction. Ethyl acetate was u...

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Veröffentlicht in:	Biochemical engineering journal 2005-12, Vol.27 (1), p.66-71
Hauptverfasser:	Kasture, Sangita M., Varma, Rita, Kalkote, Uttam R., Nene, Sanjay, Kulkarni, Bhaskar D.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Benzodioxan-2-carboxylic acid Biological and medical sciences Biotechnology Candida Candida antarctica Doxazosin Enantio selectivity Enantiomeric ratio Ethyl 1,4-benzodioxan-2-carboxylate Ethyl acetate Fundamental and applied biological sciences. Psychology Lipases Transesterfication
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