p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease

The mechanisms that regulate NK cell trafficking are unclear. Phosphoinositide-3 kinases (PI3K) control cell motility and the p110γ and p110δ isoforms are mostly expressed in leukocytes, where they transduce signals downstream of G protein coupled receptors (GPCR) or tyrosine kinase receptors, respe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-04, Vol.106 (14), p.5795-5800
Hauptverfasser:	Saudemont, Aurore, Garçon, Fabien, Yadi, Hakim, Roche-Molina, Marta, Kim, Nayoung, Segonds-Pichon, Anne, Martín-Fontecha, Alfonso, Okkenhaug, Klaus, Colucci, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal migration behavior Biological Sciences Chemokines Chemotaxis Mice Natural killer cells Phosphatidylinositols Physiological regulation Protein isoforms T lymphocytes Tumors
Online-Zugang:	Volltext
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