Anti-inflammatory activities of methanol extracts from various seaweed species
Thirty-seven species of common seaweeds from the coast of Korea were screened for anti-inflammatory activity Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate. At 40 mg ml(-1) of extract, edema was strongly suppressed by the seawe...
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| Veröffentlicht in: | Journal of environmental biology 2008-07, Vol.29 (4), p.465-469 |
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| container_title | Journal of environmental biology |
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| creator | Khan, Mohammed N A Choi, Jae Suk Lee, Min Chul Kim, Eliya Nam, Taek Jeong Fujii, Hitoshi Hong, Yong Ki |
| description | Thirty-seven species of common seaweeds from the coast of Korea were screened for anti-inflammatory activity Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate. At 40 mg ml(-1) of extract, edema was strongly suppressed by the seaweeds Undaria pinnatifida and Ulva linza, with relative inhibition of 85 and 84%, respectively These two seaweeds also showed the greatest suppression of erythema, with inhibition of 78 and 70%, respectively IC50 values of U. pinnatifida were 10, 15, and 18 mg ml(-1) when inflammation symptoms of edema, erythema, and blood flow, respectively were measured. The IC50 of U. linza was 20, 26, and 31 mg ml(-1) when edema, erythema, and blood flow, respectively, were measured. A linear correlation among inhibition rates of edema, erythema, and blood flow was observed with high confidence. |
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At 40 mg ml(-1) of extract, edema was strongly suppressed by the seaweeds Undaria pinnatifida and Ulva linza, with relative inhibition of 85 and 84%, respectively These two seaweeds also showed the greatest suppression of erythema, with inhibition of 78 and 70%, respectively IC50 values of U. pinnatifida were 10, 15, and 18 mg ml(-1) when inflammation symptoms of edema, erythema, and blood flow, respectively were measured. The IC50 of U. linza was 20, 26, and 31 mg ml(-1) when edema, erythema, and blood flow, respectively, were measured. A linear correlation among inhibition rates of edema, erythema, and blood flow was observed with high confidence.</description><identifier>ISSN: 0254-8704</identifier><identifier>PMID: 19195382</identifier><language>eng</language><publisher>India</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Blood Flow Velocity ; Dose-Response Relationship, Drug ; Ear - pathology ; Edema - chemically induced ; Edema - drug therapy ; Edema - metabolism ; Edema - pathology ; Erythema - chemically induced ; Erythema - drug therapy ; Erythema - metabolism ; Erythema - pathology ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - metabolism ; Inflammation - pathology ; Inhibitory Concentration 50 ; Korea ; Methanol - chemistry ; Mice ; Mice, Inbred BALB C ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Seaweed - chemistry ; Seaweed - classification ; Tetradecanoylphorbol Acetate ; Ulva ; Undaria pinnatifida</subject><ispartof>Journal of environmental biology, 2008-07, Vol.29 (4), p.465-469</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19195382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shin, HW</contributor><creatorcontrib>Khan, Mohammed N A</creatorcontrib><creatorcontrib>Choi, Jae Suk</creatorcontrib><creatorcontrib>Lee, Min Chul</creatorcontrib><creatorcontrib>Kim, Eliya</creatorcontrib><creatorcontrib>Nam, Taek Jeong</creatorcontrib><creatorcontrib>Fujii, Hitoshi</creatorcontrib><creatorcontrib>Hong, Yong Ki</creatorcontrib><title>Anti-inflammatory activities of methanol extracts from various seaweed species</title><title>Journal of environmental biology</title><addtitle>J Environ Biol</addtitle><description>Thirty-seven species of common seaweeds from the coast of Korea were screened for anti-inflammatory activity Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate. At 40 mg ml(-1) of extract, edema was strongly suppressed by the seaweeds Undaria pinnatifida and Ulva linza, with relative inhibition of 85 and 84%, respectively These two seaweeds also showed the greatest suppression of erythema, with inhibition of 78 and 70%, respectively IC50 values of U. pinnatifida were 10, 15, and 18 mg ml(-1) when inflammation symptoms of edema, erythema, and blood flow, respectively were measured. The IC50 of U. linza was 20, 26, and 31 mg ml(-1) when edema, erythema, and blood flow, respectively, were measured. A linear correlation among inhibition rates of edema, erythema, and blood flow was observed with high confidence.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Blood Flow Velocity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ear - pathology</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Edema - metabolism</subject><subject>Edema - pathology</subject><subject>Erythema - chemically induced</subject><subject>Erythema - drug therapy</subject><subject>Erythema - metabolism</subject><subject>Erythema - pathology</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Inhibitory Concentration 50</subject><subject>Korea</subject><subject>Methanol - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Seaweed - chemistry</subject><subject>Seaweed - classification</subject><subject>Tetradecanoylphorbol Acetate</subject><subject>Ulva</subject><subject>Undaria pinnatifida</subject><issn>0254-8704</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtPwzAQhH0A0ar0LyCfuEVy_EpyrCpeUlUuvUcbZy2M4iTYTqH_HkuUuXyHmV3tzg1ZM65kUVdMrsg2xk-WJRpeqeaOrMqmbJSo-Zocd2NyhRvtAN5DmsKFgknu7JLDSCdLPaYPGKeB4k8K2YrUhsnTMwQ3LZFGhG_EnsYZTZ64J7cWhojbKzfk9Px02r8Wh_eXt_3uUMxcslRAZzmUqgddMtCyN32lJWdKMq3L3mjIkNqqmoGS-QXFhNZoZFfXyhotNuTxb-0cpq8FY2q9iwaHAUbMV7WccaFYXeXgwzW4dB77dg7OQ7i0_wWIX_PmV0Q</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Khan, Mohammed N A</creator><creator>Choi, Jae Suk</creator><creator>Lee, Min Chul</creator><creator>Kim, Eliya</creator><creator>Nam, Taek Jeong</creator><creator>Fujii, Hitoshi</creator><creator>Hong, Yong Ki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7ST</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>20080701</creationdate><title>Anti-inflammatory activities of methanol extracts from various seaweed species</title><author>Khan, Mohammed N A ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Blood Flow Velocity Dose-Response Relationship, Drug Ear - pathology Edema - chemically induced Edema - drug therapy Edema - metabolism Edema - pathology Erythema - chemically induced Erythema - drug therapy Erythema - metabolism Erythema - pathology Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inhibitory Concentration 50 Korea Methanol - chemistry Mice Mice, Inbred BALB C Plant Extracts - pharmacology Plant Extracts - therapeutic use Seaweed - chemistry Seaweed - classification Tetradecanoylphorbol Acetate Ulva Undaria pinnatifida |
| title | Anti-inflammatory activities of methanol extracts from various seaweed species |
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