Studies of polyether toxins in the marine phytoplankton, Dinophysis acuta, in Ireland using multiple tandem mass spectrometry
Diarretic shellfish poisoning (DSP) is a toxic syndrome associated with the consumption of bivalve molluscs. The DSP toxins are polyether compounds, which include okadaic acid (OA), dinophysistoxins (DTXs), pectenotoxins (PTXs) and pectenotoxin seco acids (PTX2SAs). These toxins originate in marine...
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| Veröffentlicht in: | Toxicon (Oxford) 2004-12, Vol.44 (8), p.919-926 |
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| creator | Puente, Patricia Fernández Sáez, María José Fidalgo Hamilton, Brett Furey, Ambrose James, Kevin J. |
| description | Diarretic shellfish poisoning (DSP) is a toxic syndrome associated with the consumption of bivalve molluscs. The DSP toxins are polyether compounds, which include okadaic acid (OA), dinophysistoxins (DTXs), pectenotoxins (PTXs) and pectenotoxin seco acids (PTX2SAs). These toxins originate in marine dinoflagellates, including
Dinophysis spp. Phytoplankton samples were collected from the southwest coast of Ireland and
D. acuta was the predominant species. Monocultures of
D. acuta cells were prepared by hand picking from microscope slides in order to confirm their toxin profiles. There was a remarkable consistency in the toxin profiles in all of the phytoplankton samples collected during the summer months, irrespective of location, depth or mesh size. Analysis using liquid chromatography—multiple tandem mass spectrometry (LC-MS/MS) revealed that DTX2 and OA were the predominant toxins at a consistent ratio. The average toxin composition was: DTX2 (53±5%), OA (26.5±2.3%) and total pectenotoxins (20.8±4.7%). Toxin profiles in
D. acuta from Europe were distinctly different from those found in New Zealand, where PTX2 was the predominant toxin and DTX2 was absent. |
| doi_str_mv | 10.1016/j.toxicon.2004.09.001 |
| format | Article |
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Dinophysis spp. Phytoplankton samples were collected from the southwest coast of Ireland and
D. acuta was the predominant species. Monocultures of
D. acuta cells were prepared by hand picking from microscope slides in order to confirm their toxin profiles. There was a remarkable consistency in the toxin profiles in all of the phytoplankton samples collected during the summer months, irrespective of location, depth or mesh size. Analysis using liquid chromatography—multiple tandem mass spectrometry (LC-MS/MS) revealed that DTX2 and OA were the predominant toxins at a consistent ratio. The average toxin composition was: DTX2 (53±5%), OA (26.5±2.3%) and total pectenotoxins (20.8±4.7%). Toxin profiles in
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Dinophysis spp. Phytoplankton samples were collected from the southwest coast of Ireland and
D. acuta was the predominant species. Monocultures of
D. acuta cells were prepared by hand picking from microscope slides in order to confirm their toxin profiles. There was a remarkable consistency in the toxin profiles in all of the phytoplankton samples collected during the summer months, irrespective of location, depth or mesh size. Analysis using liquid chromatography—multiple tandem mass spectrometry (LC-MS/MS) revealed that DTX2 and OA were the predominant toxins at a consistent ratio. The average toxin composition was: DTX2 (53±5%), OA (26.5±2.3%) and total pectenotoxins (20.8±4.7%). Toxin profiles in
D. acuta from Europe were distinctly different from those found in New Zealand, where PTX2 was the predominant toxin and DTX2 was absent.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bivalvia</subject><subject>Chromatography, Liquid</subject><subject>Diarrhetic shellfish poisoning</subject><subject>Dinoflagellates</subject><subject>Dinoflagellida - chemistry</subject><subject>Dinophysis</subject><subject>Dinophysis acuta</subject><subject>DSP</subject><subject>Ethers, Cyclic - analysis</subject><subject>Ethers, Cyclic - chemistry</subject><subject>Foodborne Diseases - prevention & control</subject><subject>Ireland</subject><subject>LC-MS/MS</subject><subject>Marine</subject><subject>Marine toxins</subject><subject>Marine Toxins - analysis</subject><subject>Marine Toxins - chemistry</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Mollusca</subject><subject>Plant poisons toxicology</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v3CAQhlHVqNmm_QmtuLSn2Bls8MepitKvSJFyaHtGLIwbtja4gKvsof-9WGspx56A4eFl5iHkDYOSAWuuDmXyj1Z7V1YAvIS-BGDPyI51bV_UTMBzsssXrICMn5OXMR4AoO765gU5Z0LU0Ld8R_5-S4uxGKkf6OzHI6YHDHSNdpFaR_ORTipYh3R-OCY_j8r9St5d0o_W-VyKNlKll6QuV_w2YAYMXaJ1P-m0jMnOI9KUazjloBhpnFGn4CdM4fiKnA1qjPh6Wy_Ij8-fvt98Le7uv9zeXN8VmnddKrRRTPSt0UzwKu8YQ1OBaHnDOqOgM3vGWYX9Hhg2Ax-qflAwYMsZ6wQXQ31B3p9y5-B_LxiTnGzUOOZe0S9RVlDVvO66DIoTqIOPMeAg52Dz_EfJQK7e5UFu3uXqXUIvs_f87u32wbKf0Dy92kRn4N0GqKjVOATltI1PXFPnecQa9OHEYdbxx2KQUVt0Go0N2Zs03v6nlX8biKYK</recordid><startdate>20041215</startdate><enddate>20041215</enddate><creator>Puente, Patricia Fernández</creator><creator>Sáez, María José Fidalgo</creator><creator>Hamilton, Brett</creator><creator>Furey, Ambrose</creator><creator>James, Kevin J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TN</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H97</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20041215</creationdate><title>Studies of polyether toxins in the marine phytoplankton, Dinophysis acuta, in Ireland using multiple tandem mass spectrometry</title><author>Puente, Patricia Fernández ; 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The DSP toxins are polyether compounds, which include okadaic acid (OA), dinophysistoxins (DTXs), pectenotoxins (PTXs) and pectenotoxin seco acids (PTX2SAs). These toxins originate in marine dinoflagellates, including
Dinophysis spp. Phytoplankton samples were collected from the southwest coast of Ireland and
D. acuta was the predominant species. Monocultures of
D. acuta cells were prepared by hand picking from microscope slides in order to confirm their toxin profiles. There was a remarkable consistency in the toxin profiles in all of the phytoplankton samples collected during the summer months, irrespective of location, depth or mesh size. Analysis using liquid chromatography—multiple tandem mass spectrometry (LC-MS/MS) revealed that DTX2 and OA were the predominant toxins at a consistent ratio. The average toxin composition was: DTX2 (53±5%), OA (26.5±2.3%) and total pectenotoxins (20.8±4.7%). Toxin profiles in
D. acuta from Europe were distinctly different from those found in New Zealand, where PTX2 was the predominant toxin and DTX2 was absent.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15530974</pmid><doi>10.1016/j.toxicon.2004.09.001</doi><tpages>8</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 2004-12, Vol.44 (8), p.919-926 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Bivalvia Chromatography, Liquid Diarrhetic shellfish poisoning Dinoflagellates Dinoflagellida - chemistry Dinophysis Dinophysis acuta DSP Ethers, Cyclic - analysis Ethers, Cyclic - chemistry Foodborne Diseases - prevention & control Ireland LC-MS/MS Marine Marine toxins Marine Toxins - analysis Marine Toxins - chemistry Mass Spectrometry - methods Medical sciences Molecular Structure Mollusca Plant poisons toxicology Toxicology |
| title | Studies of polyether toxins in the marine phytoplankton, Dinophysis acuta, in Ireland using multiple tandem mass spectrometry |
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