Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-05, Vol.54 (36), p.4521-4524
Hauptverfasser: Opoku-Temeng, Clement, Dayal, Neetu, Hernandez, Delmis E, Naganna, N, Sintim, Herman O
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Cyclin-dependent kinases
Kinases
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Zusammenfassung:Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01154k