Elevated Cell-Free Mitochondrial DNA in Filtered Plasma Is Associated With HIV Infection and Inflammation

BACKGROUND:Increased cell-free DNA levels are associated with poor health outcomes, and cell-free mitochondrial DNA (cf-mtDNA) has proinflammatory properties. Given that HIV infection is associated with chronic inflammation, we investigated the relationship between cf-mtDNA and proinflammatory cytok...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2018-05, Vol.78 (1), p.111-118
Hauptverfasser:	Arshad, Omair, Gadawska, Izabella, Sattha, Beheroze, Côté, Hélène C F, Hsieh, Anthony Y Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Aged Aging AIDS/HIV Anti-Retroviral Agents - therapeutic use Antiviral agents Biomarkers - blood Blood Canada Cell-Free Nucleic Acids - blood Centrifugation Child Child, Preschool Children Chronic infection Cross-Sectional Studies Demographics Deoxyribonucleic acid DNA DNA, Mitochondrial - blood Enzyme-linked immunosorbent assay Female Filtration HIV HIV Infections - diagnosis Human immunodeficiency virus Humans Immunity (Disease) Inflammation Inflammation - diagnosis Interleukin 6 Interleukin-6 - blood Interleukins Leukocyte Count Leukocytes Male Middle Aged Mitochondria Mitochondrial DNA Multivariate Analysis Plasma Plasma - chemistry Platelets Polymerase chain reaction Retrospective Studies Viral Load Young Adult
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