Longer diabetes duration reduces myocardial blood flow in remote myocardium assessed by dynamic myocardial CT perfusion
To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion. We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the decon...
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| Veröffentlicht in: | Journal of diabetes and its complications 2018-06, Vol.32 (6), p.609-615 |
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| container_title | Journal of diabetes and its complications |
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| creator | Tomizawa, Nobuo Fujino, Yusuke Kamitani, Masaru Chou, Shengpu Yamamoto, Kodai Inoh, Shinichi Nojo, Takeshi Nakamura, Sunao |
| description | To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion.
We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis.
A weak but significantly negative relationship was present between diabetes duration and MBF (R2 = 0.05, p 8 years was 13% lower than that of the remaining patients (1.11 ± 0.35 vs 1.28 ± 0.27 ml min−1 g−1, p |
| doi_str_mv | 10.1016/j.jdiacomp.2018.03.003 |
| format | Article |
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We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis.
A weak but significantly negative relationship was present between diabetes duration and MBF (R2 = 0.05, p < 0.01). The average MBF of patients with a duration of >8 years was 13% lower than that of the remaining patients (1.11 ± 0.35 vs 1.28 ± 0.27 ml min−1 g−1, p < 0.01). Duration of one year was associated with a 6% increased risk for low MBF (<1.18 ml min−1 g−1) (odds ratio 1.06, 95% confidence interval 1.01–1.12, p < 0.05). Calcium score was also a significant factor for low MBF (odds ratio 1.08 (per 100 Agatston units), 95% confidence interval 1.01–1.17, p < 0.05).
Longer diabetes duration is associated with lower MBF independent of conventional cardiac risk factors or the presence of coronary stenosis.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2018.03.003</identifier><identifier>PMID: 29627375</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>64-row CT ; Adenosine ; Caffeine ; Cardiovascular disease ; Coronary vessels ; CT perfusion ; Diabetes ; Diabetes duration ; Diabetic retinopathy ; Family medical history ; Heart rate ; Hypertension ; Iodine ; Medical imaging ; Myocardial blood flow ; Patients ; Risk factors ; Voronoi method</subject><ispartof>Journal of diabetes and its complications, 2018-06, Vol.32 (6), p.609-615</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-8f574874f8478b4d10f917eac2a064635d4db1bb31161617a3f4974ed109d7403</citedby><cites>FETCH-LOGICAL-c396t-8f574874f8478b4d10f917eac2a064635d4db1bb31161617a3f4974ed109d7403</cites><orcidid>0000-0002-1619-4407 ; 0000-0002-4895-882X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1056872717316665$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29627375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomizawa, Nobuo</creatorcontrib><creatorcontrib>Fujino, Yusuke</creatorcontrib><creatorcontrib>Kamitani, Masaru</creatorcontrib><creatorcontrib>Chou, Shengpu</creatorcontrib><creatorcontrib>Yamamoto, Kodai</creatorcontrib><creatorcontrib>Inoh, Shinichi</creatorcontrib><creatorcontrib>Nojo, Takeshi</creatorcontrib><creatorcontrib>Nakamura, Sunao</creatorcontrib><title>Longer diabetes duration reduces myocardial blood flow in remote myocardium assessed by dynamic myocardial CT perfusion</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion.
We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis.
A weak but significantly negative relationship was present between diabetes duration and MBF (R2 = 0.05, p < 0.01). The average MBF of patients with a duration of >8 years was 13% lower than that of the remaining patients (1.11 ± 0.35 vs 1.28 ± 0.27 ml min−1 g−1, p < 0.01). Duration of one year was associated with a 6% increased risk for low MBF (<1.18 ml min−1 g−1) (odds ratio 1.06, 95% confidence interval 1.01–1.12, p < 0.05). Calcium score was also a significant factor for low MBF (odds ratio 1.08 (per 100 Agatston units), 95% confidence interval 1.01–1.17, p < 0.05).
Longer diabetes duration is associated with lower MBF independent of conventional cardiac risk factors or the presence of coronary stenosis.</description><subject>64-row CT</subject><subject>Adenosine</subject><subject>Caffeine</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>CT perfusion</subject><subject>Diabetes</subject><subject>Diabetes duration</subject><subject>Diabetic retinopathy</subject><subject>Family medical history</subject><subject>Heart rate</subject><subject>Hypertension</subject><subject>Iodine</subject><subject>Medical imaging</subject><subject>Myocardial blood flow</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Voronoi method</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU-L1TAUxYMozjj6FYaAGzetN3-atDvlMerAAzcjuAtpcispbfNMWof37c3jzQziZkgg4d7fObnkEHLNoGbA1MexHn2wLs6HmgNraxA1gHhBLlmrRSUV_HxZ7tCoqtVcX5A3OY8AoJqGvSYXvFNcC91ckvt9XH5hosWsxxUz9Vuya4gLTeg3VwrzMTqbSn-i_RSjp8MU72k4AXNc8am_zdTmjGV72h-pPy52Du5f-e6OHjANWy72b8mrwU4Z3z2cV-THl5u73bdq__3r7e7zvnKiU2vVDo2WrZZDK3XbS89g6JhG67gFJZVovPQ963vBmCpLWzHITkssYOe1BHFFPpx9Dyn-3jCvZg7Z4TTZBeOWDQcuJCjOeUHf_4eOcUtLma5Qkqu2Y60qlDpTLsWcEw7mkMJs09EwMKdozGgeozGnaAwIU6IpwusH-62f0T_JHrMowKczgOU__gRMJruAi0MfErrV-Biee-MvGbGjvQ</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Tomizawa, Nobuo</creator><creator>Fujino, Yusuke</creator><creator>Kamitani, Masaru</creator><creator>Chou, Shengpu</creator><creator>Yamamoto, Kodai</creator><creator>Inoh, Shinichi</creator><creator>Nojo, Takeshi</creator><creator>Nakamura, Sunao</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1619-4407</orcidid><orcidid>https://orcid.org/0000-0002-4895-882X</orcidid></search><sort><creationdate>201806</creationdate><title>Longer diabetes duration reduces myocardial blood flow in remote myocardium assessed by dynamic myocardial CT perfusion</title><author>Tomizawa, Nobuo ; Fujino, Yusuke ; Kamitani, Masaru ; Chou, Shengpu ; Yamamoto, Kodai ; Inoh, Shinichi ; Nojo, Takeshi ; Nakamura, Sunao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-8f574874f8478b4d10f917eac2a064635d4db1bb31161617a3f4974ed109d7403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>64-row CT</topic><topic>Adenosine</topic><topic>Caffeine</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>CT perfusion</topic><topic>Diabetes</topic><topic>Diabetes duration</topic><topic>Diabetic retinopathy</topic><topic>Family medical history</topic><topic>Heart rate</topic><topic>Hypertension</topic><topic>Iodine</topic><topic>Medical imaging</topic><topic>Myocardial blood flow</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Voronoi method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomizawa, Nobuo</creatorcontrib><creatorcontrib>Fujino, Yusuke</creatorcontrib><creatorcontrib>Kamitani, Masaru</creatorcontrib><creatorcontrib>Chou, Shengpu</creatorcontrib><creatorcontrib>Yamamoto, Kodai</creatorcontrib><creatorcontrib>Inoh, Shinichi</creatorcontrib><creatorcontrib>Nojo, Takeshi</creatorcontrib><creatorcontrib>Nakamura, Sunao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library (ProQuest)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomizawa, Nobuo</au><au>Fujino, Yusuke</au><au>Kamitani, Masaru</au><au>Chou, Shengpu</au><au>Yamamoto, Kodai</au><au>Inoh, Shinichi</au><au>Nojo, Takeshi</au><au>Nakamura, Sunao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longer diabetes duration reduces myocardial blood flow in remote myocardium assessed by dynamic myocardial CT perfusion</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2018-06</date><risdate>2018</risdate><volume>32</volume><issue>6</issue><spage>609</spage><epage>615</epage><pages>609-615</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion.
We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis.
A weak but significantly negative relationship was present between diabetes duration and MBF (R2 = 0.05, p < 0.01). The average MBF of patients with a duration of >8 years was 13% lower than that of the remaining patients (1.11 ± 0.35 vs 1.28 ± 0.27 ml min−1 g−1, p < 0.01). Duration of one year was associated with a 6% increased risk for low MBF (<1.18 ml min−1 g−1) (odds ratio 1.06, 95% confidence interval 1.01–1.12, p < 0.05). Calcium score was also a significant factor for low MBF (odds ratio 1.08 (per 100 Agatston units), 95% confidence interval 1.01–1.17, p < 0.05).
Longer diabetes duration is associated with lower MBF independent of conventional cardiac risk factors or the presence of coronary stenosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29627375</pmid><doi>10.1016/j.jdiacomp.2018.03.003</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1619-4407</orcidid><orcidid>https://orcid.org/0000-0002-4895-882X</orcidid></addata></record> |
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| ispartof | Journal of diabetes and its complications, 2018-06, Vol.32 (6), p.609-615 |
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| source | Elsevier ScienceDirect Journals |
| subjects | 64-row CT Adenosine Caffeine Cardiovascular disease Coronary vessels CT perfusion Diabetes Diabetes duration Diabetic retinopathy Family medical history Heart rate Hypertension Iodine Medical imaging Myocardial blood flow Patients Risk factors Voronoi method |
| title | Longer diabetes duration reduces myocardial blood flow in remote myocardium assessed by dynamic myocardial CT perfusion |
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