Poor prognosis in Epstein–Barr virus-negative gastric cancer with lymphoid stroma is associated with immune phenotype

Background Gastric cancer with lymphoid stroma (GCLS) is pathologically characterized by poorly developed tubular structures with a prominent lymphocytic infiltration. Its clinical and prognostic features differ in patients positive and negative for Epstein–Barr virus (EBV) infection. This study ana...

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Veröffentlicht in:	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2018-11, Vol.21 (6), p.925-935
Hauptverfasser:	Cho, Charles J., Kang, Hyo Jeong, Ryu, Yeon-Mi, Park, Young Soo, Jeong, Hui Jeong, Park, Young-Mi, Lim, Hyun, Lee, Jeong Hoon, Song, Ho June, Jung, Hwoon-Yong, Kim, Sang-Yeob, Myung, Seung-Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adult Aged Apoptosis B7-H1 Antigen - metabolism Biomarkers, Tumor - immunology Biomarkers, Tumor - metabolism Cancer Research CD3 antigen CD3 Complex - metabolism CD8 antigen CD8-Positive T-Lymphocytes - pathology Cell death Cell density Epstein-Barr virus Epstein-Barr Virus Infections - immunology Epstein-Barr Virus Infections - pathology Epstein-Barr Virus Infections - virology Female Gastric cancer Gastroenterology Herpesvirus 4, Human - pathogenicity Humans Lymphocytes T Lymphocytes, Tumor-Infiltrating - pathology Lymphoid Tissue - pathology Male Medical prognosis Medicine Medicine & Public Health Metastases Middle Aged Oncology Original Article PD-1 protein PD-L1 protein Phenotypes Prognosis Programmed Cell Death 1 Receptor - metabolism Retrospective Studies Stomach Neoplasms - immunology Stomach Neoplasms - mortality Stomach Neoplasms - surgery Stomach Neoplasms - virology Stroma Surgical Oncology Survival Analysis Tumor cells Tumor Microenvironment - immunology Tumor-infiltrating lymphocytes
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